Genetics and molecular biology of familial combined hyperlipidemia

Peter O. Kwiterovich

Research output: Contribution to journalArticlepeer-review

63 Scopus citations


Familial combined hyperlipidemia (FCHL) is a dyslipidemic syndrome prevalent in patients with coronary artery disease. Other phenotypes that appear to have a kinship with FCHL include hyperapobetalipoproteinemia, LDL subclass pattern B, familial dyslipidemic hypertension, and syndrome X. The metabolic, genetic, and molecular basis of FCHL is heterogeneous. This review discusses the influence of eight putative loci as a basis for this heterogeneity. Further understanding of the fundamental defects underlying FCHL and related syndromes may provide important insights into the pathophysiology of coronary artery disease.

Original languageEnglish (US)
Pages (from-to)133-143
Number of pages11
JournalCurrent Opinion in Lipidology
Issue number2
StatePublished - Jan 1 1993

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Genetics
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine
  • Cell Biology


Dive into the research topics of 'Genetics and molecular biology of familial combined hyperlipidemia'. Together they form a unique fingerprint.

Cite this