Genetically Related Choriocarcinoma Developing 5 Yr after a Complete Hydatidiform Mole and Simulating a Cornual Ectopic Pregnancy

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Abstract

Persistent gestational trophoblastic disease can arise from any type of antecedent pregnancy, including molar and tubal pregnancies. While most cases of persistent gestational trophoblastic disease present within the first year following initial diagnosis, recurrence has rarely been reported many years after initial diagnosis. Distinguishing recurrence from a new independent lesion is clinically important. A 25-yr-old woman presented with a mass in the right uterine cornu that was discontiguous with the endometrial cavity and was associated with an elevated serum human chorionic gonadotropin level. She had a history of an invasive complete hydatidiform mole with lung involvement treated with chemotherapy 5 yr prior. Wedge resection of the right cornu was performed due to concern for a cornual ectopic pregnancy. Pathologic evaluation demonstrated a choriocarcinoma. Molecular genotyping confirmed the tumor as recurrent disease genetically related to the prior complete hydatidiform mole. She completed 4 cycles of EMA-CO therapy, and has been disease-free with undetectable serum human chorionic gonadotropin level for 2 yr.

Original languageEnglish (US)
JournalInternational Journal of Gynecological Pathology
DOIs
StatePublished - Jan 1 2019

Fingerprint

Hydatidiform Mole
Choriocarcinoma
Ectopic Pregnancy
Gestational Trophoblastic Disease
Chorionic Gonadotropin
Invasive Hydatidiform Mole
Tubal Pregnancy
Recurrence
Carbon Monoxide
Serum
Drug Therapy
Pregnancy
Lung
Cornual Pregnancy
Neoplasms
Therapeutics

Keywords

  • Choriocarcinoma
  • Cornual ectopic pregnancy
  • Gestational trophoblastic disease
  • Hydatidiform mole
  • Molecular genotyping

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Obstetrics and Gynecology

Cite this

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title = "Genetically Related Choriocarcinoma Developing 5 Yr after a Complete Hydatidiform Mole and Simulating a Cornual Ectopic Pregnancy",
abstract = "Persistent gestational trophoblastic disease can arise from any type of antecedent pregnancy, including molar and tubal pregnancies. While most cases of persistent gestational trophoblastic disease present within the first year following initial diagnosis, recurrence has rarely been reported many years after initial diagnosis. Distinguishing recurrence from a new independent lesion is clinically important. A 25-yr-old woman presented with a mass in the right uterine cornu that was discontiguous with the endometrial cavity and was associated with an elevated serum human chorionic gonadotropin level. She had a history of an invasive complete hydatidiform mole with lung involvement treated with chemotherapy 5 yr prior. Wedge resection of the right cornu was performed due to concern for a cornual ectopic pregnancy. Pathologic evaluation demonstrated a choriocarcinoma. Molecular genotyping confirmed the tumor as recurrent disease genetically related to the prior complete hydatidiform mole. She completed 4 cycles of EMA-CO therapy, and has been disease-free with undetectable serum human chorionic gonadotropin level for 2 yr.",
keywords = "Choriocarcinoma, Cornual ectopic pregnancy, Gestational trophoblastic disease, Hydatidiform mole, Molecular genotyping",
author = "Chau, {Danielle B.} and Anna Beavis and Ronnett, {Brigitte Maria} and Erik Jenson and Christopher Gocke and Jean Anderson and {Nickles Fader}, {Amanda Nickles} and Rebecca Stone",
year = "2019",
month = "1",
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doi = "10.1097/PGP.0000000000000607",
language = "English (US)",
journal = "International Journal of Gynecological Pathology",
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AU - Chau, Danielle B.

AU - Beavis, Anna

AU - Ronnett, Brigitte Maria

AU - Jenson, Erik

AU - Gocke, Christopher

AU - Anderson, Jean

AU - Nickles Fader, Amanda Nickles

AU - Stone, Rebecca

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Persistent gestational trophoblastic disease can arise from any type of antecedent pregnancy, including molar and tubal pregnancies. While most cases of persistent gestational trophoblastic disease present within the first year following initial diagnosis, recurrence has rarely been reported many years after initial diagnosis. Distinguishing recurrence from a new independent lesion is clinically important. A 25-yr-old woman presented with a mass in the right uterine cornu that was discontiguous with the endometrial cavity and was associated with an elevated serum human chorionic gonadotropin level. She had a history of an invasive complete hydatidiform mole with lung involvement treated with chemotherapy 5 yr prior. Wedge resection of the right cornu was performed due to concern for a cornual ectopic pregnancy. Pathologic evaluation demonstrated a choriocarcinoma. Molecular genotyping confirmed the tumor as recurrent disease genetically related to the prior complete hydatidiform mole. She completed 4 cycles of EMA-CO therapy, and has been disease-free with undetectable serum human chorionic gonadotropin level for 2 yr.

AB - Persistent gestational trophoblastic disease can arise from any type of antecedent pregnancy, including molar and tubal pregnancies. While most cases of persistent gestational trophoblastic disease present within the first year following initial diagnosis, recurrence has rarely been reported many years after initial diagnosis. Distinguishing recurrence from a new independent lesion is clinically important. A 25-yr-old woman presented with a mass in the right uterine cornu that was discontiguous with the endometrial cavity and was associated with an elevated serum human chorionic gonadotropin level. She had a history of an invasive complete hydatidiform mole with lung involvement treated with chemotherapy 5 yr prior. Wedge resection of the right cornu was performed due to concern for a cornual ectopic pregnancy. Pathologic evaluation demonstrated a choriocarcinoma. Molecular genotyping confirmed the tumor as recurrent disease genetically related to the prior complete hydatidiform mole. She completed 4 cycles of EMA-CO therapy, and has been disease-free with undetectable serum human chorionic gonadotropin level for 2 yr.

KW - Choriocarcinoma

KW - Cornual ectopic pregnancy

KW - Gestational trophoblastic disease

KW - Hydatidiform mole

KW - Molecular genotyping

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