Genetically engineered models relevant to neurodegenerative disorders: Their value for understanding disease mechanisms and designing/testing experimental therapeutics

P. C. Wong, H. Cai, D. R. Borchelt, D. L. Price

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Significant progress in the identification of disease-specific genes for a variety of neurodegenerative diseases have provided opportunities to understand molecular mechanisms and to test experimental therapeutic for these disorders. Recent works on clarifying the selective vulnerability of neurons and pathogenic mechanisms using genetically engineered mouse models of familial forms of Alzheimer's disease and motor neuron disease will be reviewed.

    Original languageEnglish (US)
    Pages (from-to)233-257
    Number of pages25
    JournalJournal of Molecular Neuroscience
    Volume17
    Issue number2
    DOIs
    StatePublished - 2001

    Keywords

    • Disease mechanisms
    • Experimental therapeutics
    • Neurodegenerative diseases
    • Selective vulnerability
    • Transgenic models

    ASJC Scopus subject areas

    • Neuroscience(all)
    • Biochemistry
    • Genetics

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