Abstract
Significant progress in the identification of disease-specific genes for a variety of neurodegenerative diseases have provided opportunities to understand molecular mechanisms and to test experimental therapeutic for these disorders. Recent works on clarifying the selective vulnerability of neurons and pathogenic mechanisms using genetically engineered mouse models of familial forms of Alzheimer's disease and motor neuron disease will be reviewed.
Original language | English (US) |
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Pages (from-to) | 233-257 |
Number of pages | 25 |
Journal | Journal of Molecular Neuroscience |
Volume | 17 |
Issue number | 2 |
DOIs | |
State | Published - 2001 |
Keywords
- Disease mechanisms
- Experimental therapeutics
- Neurodegenerative diseases
- Selective vulnerability
- Transgenic models
ASJC Scopus subject areas
- General Neuroscience
- Biochemistry
- Genetics