Genetically determined deficiency of the third component of complement in the dog

Jerry A. Winkelstein; Linda Collins Cork; Diane E. Griffin; John W. Griffin; Robert J. Adams; Donald L. Price

doi:10.1126/science.7233211

Genetically determined deficiency of the third component of complement in the dog

Jerry A. Winkelstein, Linda Collins Cork, Diane E. Griffin, John W. Griffin, Robert J. Adams, Donald L. Price

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Abstract

A genetically determined deficiency of the third component of complement (C3) has been identified in a colony of Brittany spaniels. Immunochemical methods show no detectable C3 in the serum of the affected dogs, and there is no evidence of an inhibitor of C3 in the serum. The C3 deficiency appears to be transmitted as an autosomal recessive trait.

Original language	English (US)
Pages (from-to)	1169-1170
Number of pages	2
Journal	Science
Volume	212
Issue number	4499
DOIs	https://doi.org/10.1126/science.7233211
State	Published - 1981

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title = "Genetically determined deficiency of the third component of complement in the dog",

abstract = "A genetically determined deficiency of the third component of complement (C3) has been identified in a colony of Brittany spaniels. Immunochemical methods show no detectable C3 in the serum of the affected dogs, and there is no evidence of an inhibitor of C3 in the serum. The C3 deficiency appears to be transmitted as an autosomal recessive trait.",

author = "Winkelstein, {Jerry A.} and Cork, {Linda Collins} and Griffin, {Diane E.} and Griffin, {John W.} and Adams, {Robert J.} and Price, {Donald L.}",

year = "1981",

doi = "10.1126/science.7233211",

language = "English (US)",

volume = "212",

pages = "1169--1170",

journal = "Science",

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publisher = "American Association for the Advancement of Science",

number = "4499",

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T1 - Genetically determined deficiency of the third component of complement in the dog

AU - Winkelstein, Jerry A.

AU - Cork, Linda Collins

AU - Griffin, Diane E.

AU - Griffin, John W.

AU - Adams, Robert J.

AU - Price, Donald L.

PY - 1981

Y1 - 1981

N2 - A genetically determined deficiency of the third component of complement (C3) has been identified in a colony of Brittany spaniels. Immunochemical methods show no detectable C3 in the serum of the affected dogs, and there is no evidence of an inhibitor of C3 in the serum. The C3 deficiency appears to be transmitted as an autosomal recessive trait.

AB - A genetically determined deficiency of the third component of complement (C3) has been identified in a colony of Brittany spaniels. Immunochemical methods show no detectable C3 in the serum of the affected dogs, and there is no evidence of an inhibitor of C3 in the serum. The C3 deficiency appears to be transmitted as an autosomal recessive trait.

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U2 - 10.1126/science.7233211

DO - 10.1126/science.7233211

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JO - Science

JF - Science

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Genetically determined deficiency of the third component of complement in the dog

Abstract

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