Genetic variations in nitric oxide synthase 1 adaptor protein are associated with sudden cardiac death in us white community-based populations

W. H Linda Kao, Dan Arking, Wendy S Post, Thomas D. Rea, Nona Sotoodehnia, Ronald J. Prineas, Bryan Bishe, Betty Q. Doan, Eric Boerwinkle, Bruce M. Psaty, Gordon F. Tomaselli, Josef Coresh, David S. Siscovick, Eduardo Marbán, Peter M. Spooner, Gregory L. Burke, Aravinda Chakravarti

Research output: Contribution to journalArticle

Abstract

Background-The ECG QT interval is associated with risk of sudden cardiac death (SCD). A previous genome-wide association study demonstrated that allelic variants (rs 10494366 and rs4657139) in the nitric oxide synthase 1 adaptor protein (NOSlAP), which encodes a carboxy-terminal PDZ ligand of neuronal nitric oxide synthase, are associated with the QT interval in white adults. The present analysis was conducted to validate the association between NOSlAP variants and the QT interval and to examine the association with SCD in a combined population of 19 295 black and white adults from the Atherosclerosis Risk In Communities Study and the Cardiovascular Health Study. Methods and Results-We examined 19 tagging single-nucleotide polymorphisms in the genomic blocks containing rs 10494366 and rs4657139 in NOSIAP. SCD was defined as a sudden pulseless condition of cardiac origin in a previously stable individual. General linear models and Cox proportional hazards regression models were used. Multiple single-nucleotide polymorphisms in NOSlAP, including rs10494366, rs4657139, and rs16847548, were significantly associated with adjusted QT interval in whites (P

Original languageEnglish (US)
Pages (from-to)940-951
Number of pages12
JournalCirculation
Volume119
Issue number7
DOIs
StatePublished - Feb 24 2009

Fingerprint

Sudden Cardiac Death
Nitric Oxide Synthase
Single Nucleotide Polymorphism
Population
Nitric Oxide Synthase Type I
Proteins
Genome-Wide Association Study
Proportional Hazards Models
Linear Models
Atherosclerosis
Electrocardiography
Ligands
Health

Keywords

  • Arrhythmia
  • Death
  • Epidemiology
  • Genetics
  • Sudden

ASJC Scopus subject areas

  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Cite this

Genetic variations in nitric oxide synthase 1 adaptor protein are associated with sudden cardiac death in us white community-based populations. / Kao, W. H Linda; Arking, Dan; Post, Wendy S; Rea, Thomas D.; Sotoodehnia, Nona; Prineas, Ronald J.; Bishe, Bryan; Doan, Betty Q.; Boerwinkle, Eric; Psaty, Bruce M.; Tomaselli, Gordon F.; Coresh, Josef; Siscovick, David S.; Marbán, Eduardo; Spooner, Peter M.; Burke, Gregory L.; Chakravarti, Aravinda.

In: Circulation, Vol. 119, No. 7, 24.02.2009, p. 940-951.

Research output: Contribution to journalArticle

Kao, WHL, Arking, D, Post, WS, Rea, TD, Sotoodehnia, N, Prineas, RJ, Bishe, B, Doan, BQ, Boerwinkle, E, Psaty, BM, Tomaselli, GF, Coresh, J, Siscovick, DS, Marbán, E, Spooner, PM, Burke, GL & Chakravarti, A 2009, 'Genetic variations in nitric oxide synthase 1 adaptor protein are associated with sudden cardiac death in us white community-based populations', Circulation, vol. 119, no. 7, pp. 940-951. https://doi.org/10.1161/CIRCULATIONAHA.108.791723
Kao, W. H Linda ; Arking, Dan ; Post, Wendy S ; Rea, Thomas D. ; Sotoodehnia, Nona ; Prineas, Ronald J. ; Bishe, Bryan ; Doan, Betty Q. ; Boerwinkle, Eric ; Psaty, Bruce M. ; Tomaselli, Gordon F. ; Coresh, Josef ; Siscovick, David S. ; Marbán, Eduardo ; Spooner, Peter M. ; Burke, Gregory L. ; Chakravarti, Aravinda. / Genetic variations in nitric oxide synthase 1 adaptor protein are associated with sudden cardiac death in us white community-based populations. In: Circulation. 2009 ; Vol. 119, No. 7. pp. 940-951.
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