Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma

A report from the InterLymph Consortium

Nathaniel Rothman, Christine F. Skibola, Sophia S. Wang, Gareth Morgan, Qing Lan, Martyn T. Smith, John J. Spinelli, Eleanor Willett, Silvia De Sanjose, Pierluigi Cocco, Sonja I. Berndt, Paul Brennan, Angela Brooks-Wilson, Sholom Wacholder, Nikolaus Becker, Patricia Hartge, Tongzhang Zheng, Eve Roman, Elizabeth A. Holly, Paolo Boffetta & 23 others Bruce Armstrong, Wendy Cozen, Martha Linet, Xavier F. Bosch, Maria Grazia Ennas, Theodore R. Holford, Richard P. Gallagher, Sara Rollinson, Paige M. Bracci, James R. Cerhan, Denise Whitby, Patrick S. Moore, Brian Leaderer, Agnes Lai, Charlotte Spink, Scott Davis, Ramon Bosch, Aldo Scarpa, Yawei Zhang, Richard K. Severson, Meredith Yeager, Stephen Chanock, Alexandra Nieters

Research output: Contribution to journalArticle

Abstract

Background: Common genetic variants in immune and inflammatory response genes can affect the risk of developing non-Hodgkin lymphoma. We aimed to test this hypothesis using previously unpublished data from eight European, Canadian, and US case-control studies of the International Lymphoma Epidemiology Consortium (InterLymph). Methods: We selected 12 single-nucleotide polymorphisms for analysis, on the basis of previous functional or association data, in nine genes that have important roles in lymphoid development, Th1/Th2 balance, and proinflammatory or anti-inflammatory pathways (IL1A, IL1RN, IL1B, IL2, IL6, IL10, TNF, LTA, and CARD15). Genotype data for one or more single-nucleotide polymorphisms were available for 3586 cases of non-Hodgkin lymphoma and for 4018 controls, and were assessed in a pooled analysis by use of a random-effects logistic regression model. Findings: The tumour necrosis factor (TNF) -308G→A polymorphism was associated with increased risk of non-Hodgkin lymphoma (p for trend=0.005), particularly for diffuse large B-cell lymphoma, the main histological subtype (odds ratio 1.29 [95% CI 1.10-1.51] for GA and 1.65 [1.16-2.34] for AA, p for trend

Original languageEnglish (US)
Pages (from-to)27-38
Number of pages12
JournalThe Lancet Oncology
Volume7
Issue number1
DOIs
StatePublished - Jan 2006
Externally publishedYes

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Interleukin-10
Non-Hodgkin's Lymphoma
Lymphoma
Epidemiology
Tumor Necrosis Factor-alpha
Single Nucleotide Polymorphism
Logistic Models
Th1-Th2 Balance
Lymphoma, Large B-Cell, Diffuse
Genes
Interleukin-2
Case-Control Studies
Interleukin-6
Anti-Inflammatory Agents
Odds Ratio
Genotype
Genetic Background

ASJC Scopus subject areas

  • Oncology

Cite this

Rothman, N., Skibola, C. F., Wang, S. S., Morgan, G., Lan, Q., Smith, M. T., ... Nieters, A. (2006). Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma: A report from the InterLymph Consortium. The Lancet Oncology, 7(1), 27-38. https://doi.org/10.1016/S1470-2045(05)70434-4

Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma : A report from the InterLymph Consortium. / Rothman, Nathaniel; Skibola, Christine F.; Wang, Sophia S.; Morgan, Gareth; Lan, Qing; Smith, Martyn T.; Spinelli, John J.; Willett, Eleanor; De Sanjose, Silvia; Cocco, Pierluigi; Berndt, Sonja I.; Brennan, Paul; Brooks-Wilson, Angela; Wacholder, Sholom; Becker, Nikolaus; Hartge, Patricia; Zheng, Tongzhang; Roman, Eve; Holly, Elizabeth A.; Boffetta, Paolo; Armstrong, Bruce; Cozen, Wendy; Linet, Martha; Bosch, Xavier F.; Ennas, Maria Grazia; Holford, Theodore R.; Gallagher, Richard P.; Rollinson, Sara; Bracci, Paige M.; Cerhan, James R.; Whitby, Denise; Moore, Patrick S.; Leaderer, Brian; Lai, Agnes; Spink, Charlotte; Davis, Scott; Bosch, Ramon; Scarpa, Aldo; Zhang, Yawei; Severson, Richard K.; Yeager, Meredith; Chanock, Stephen; Nieters, Alexandra.

In: The Lancet Oncology, Vol. 7, No. 1, 01.2006, p. 27-38.

Research output: Contribution to journalArticle

Rothman, N, Skibola, CF, Wang, SS, Morgan, G, Lan, Q, Smith, MT, Spinelli, JJ, Willett, E, De Sanjose, S, Cocco, P, Berndt, SI, Brennan, P, Brooks-Wilson, A, Wacholder, S, Becker, N, Hartge, P, Zheng, T, Roman, E, Holly, EA, Boffetta, P, Armstrong, B, Cozen, W, Linet, M, Bosch, XF, Ennas, MG, Holford, TR, Gallagher, RP, Rollinson, S, Bracci, PM, Cerhan, JR, Whitby, D, Moore, PS, Leaderer, B, Lai, A, Spink, C, Davis, S, Bosch, R, Scarpa, A, Zhang, Y, Severson, RK, Yeager, M, Chanock, S & Nieters, A 2006, 'Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma: A report from the InterLymph Consortium', The Lancet Oncology, vol. 7, no. 1, pp. 27-38. https://doi.org/10.1016/S1470-2045(05)70434-4
Rothman, Nathaniel ; Skibola, Christine F. ; Wang, Sophia S. ; Morgan, Gareth ; Lan, Qing ; Smith, Martyn T. ; Spinelli, John J. ; Willett, Eleanor ; De Sanjose, Silvia ; Cocco, Pierluigi ; Berndt, Sonja I. ; Brennan, Paul ; Brooks-Wilson, Angela ; Wacholder, Sholom ; Becker, Nikolaus ; Hartge, Patricia ; Zheng, Tongzhang ; Roman, Eve ; Holly, Elizabeth A. ; Boffetta, Paolo ; Armstrong, Bruce ; Cozen, Wendy ; Linet, Martha ; Bosch, Xavier F. ; Ennas, Maria Grazia ; Holford, Theodore R. ; Gallagher, Richard P. ; Rollinson, Sara ; Bracci, Paige M. ; Cerhan, James R. ; Whitby, Denise ; Moore, Patrick S. ; Leaderer, Brian ; Lai, Agnes ; Spink, Charlotte ; Davis, Scott ; Bosch, Ramon ; Scarpa, Aldo ; Zhang, Yawei ; Severson, Richard K. ; Yeager, Meredith ; Chanock, Stephen ; Nieters, Alexandra. / Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma : A report from the InterLymph Consortium. In: The Lancet Oncology. 2006 ; Vol. 7, No. 1. pp. 27-38.
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abstract = "Background: Common genetic variants in immune and inflammatory response genes can affect the risk of developing non-Hodgkin lymphoma. We aimed to test this hypothesis using previously unpublished data from eight European, Canadian, and US case-control studies of the International Lymphoma Epidemiology Consortium (InterLymph). Methods: We selected 12 single-nucleotide polymorphisms for analysis, on the basis of previous functional or association data, in nine genes that have important roles in lymphoid development, Th1/Th2 balance, and proinflammatory or anti-inflammatory pathways (IL1A, IL1RN, IL1B, IL2, IL6, IL10, TNF, LTA, and CARD15). Genotype data for one or more single-nucleotide polymorphisms were available for 3586 cases of non-Hodgkin lymphoma and for 4018 controls, and were assessed in a pooled analysis by use of a random-effects logistic regression model. Findings: The tumour necrosis factor (TNF) -308G→A polymorphism was associated with increased risk of non-Hodgkin lymphoma (p for trend=0.005), particularly for diffuse large B-cell lymphoma, the main histological subtype (odds ratio 1.29 [95{\%} CI 1.10-1.51] for GA and 1.65 [1.16-2.34] for AA, p for trend",
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T1 - Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma

T2 - A report from the InterLymph Consortium

AU - Rothman, Nathaniel

AU - Skibola, Christine F.

AU - Wang, Sophia S.

AU - Morgan, Gareth

AU - Lan, Qing

AU - Smith, Martyn T.

AU - Spinelli, John J.

AU - Willett, Eleanor

AU - De Sanjose, Silvia

AU - Cocco, Pierluigi

AU - Berndt, Sonja I.

AU - Brennan, Paul

AU - Brooks-Wilson, Angela

AU - Wacholder, Sholom

AU - Becker, Nikolaus

AU - Hartge, Patricia

AU - Zheng, Tongzhang

AU - Roman, Eve

AU - Holly, Elizabeth A.

AU - Boffetta, Paolo

AU - Armstrong, Bruce

AU - Cozen, Wendy

AU - Linet, Martha

AU - Bosch, Xavier F.

AU - Ennas, Maria Grazia

AU - Holford, Theodore R.

AU - Gallagher, Richard P.

AU - Rollinson, Sara

AU - Bracci, Paige M.

AU - Cerhan, James R.

AU - Whitby, Denise

AU - Moore, Patrick S.

AU - Leaderer, Brian

AU - Lai, Agnes

AU - Spink, Charlotte

AU - Davis, Scott

AU - Bosch, Ramon

AU - Scarpa, Aldo

AU - Zhang, Yawei

AU - Severson, Richard K.

AU - Yeager, Meredith

AU - Chanock, Stephen

AU - Nieters, Alexandra

PY - 2006/1

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N2 - Background: Common genetic variants in immune and inflammatory response genes can affect the risk of developing non-Hodgkin lymphoma. We aimed to test this hypothesis using previously unpublished data from eight European, Canadian, and US case-control studies of the International Lymphoma Epidemiology Consortium (InterLymph). Methods: We selected 12 single-nucleotide polymorphisms for analysis, on the basis of previous functional or association data, in nine genes that have important roles in lymphoid development, Th1/Th2 balance, and proinflammatory or anti-inflammatory pathways (IL1A, IL1RN, IL1B, IL2, IL6, IL10, TNF, LTA, and CARD15). Genotype data for one or more single-nucleotide polymorphisms were available for 3586 cases of non-Hodgkin lymphoma and for 4018 controls, and were assessed in a pooled analysis by use of a random-effects logistic regression model. Findings: The tumour necrosis factor (TNF) -308G→A polymorphism was associated with increased risk of non-Hodgkin lymphoma (p for trend=0.005), particularly for diffuse large B-cell lymphoma, the main histological subtype (odds ratio 1.29 [95% CI 1.10-1.51] for GA and 1.65 [1.16-2.34] for AA, p for trend

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