Genetic variation in the androgen receptor gene and endometrial cancer risk

Hannah P. Yang, Montserrat Garcia-Closas, James V. Lacey, Louise A. Brinton, Jolanta Lissowska, Beta Peplonska, Stephen Chanock, Mia M. Gaudet

Research output: Contribution to journalArticle

Abstract

Genetic variation in the androgen receptor (AR) gene may be associated with endometrial cancer risk based on the role of AR in regulating androgen levels. However, endometrial cancer studies reported inconsistent associations for a CAG repeat polymorphism in exon 1. Only one of these studies measured haplotype-tagging single nucleotide polymorphisms (htSNP) in AR and found statistically nonsignificant, decreased associations with endometrial cancer risk. In a population-based case-control study of 497 cases and 1,024 controls, we examined the CAG repeat polymorphism and six htSNPs (rs962458, rs6152, rs1204038, rs2361634, rs1337080, and rs1337082), which cover an estimated 80% of the known common variation in AR among Caucasian populations. CAG repeat length was not significantly associated with endometrial cancer [odds ratio per unit increase in the average number of repeats, 1.02 (95% confidence interval, 0.97-1.08); P trend = 0.29]. Minor alleles in three correlated htSNPs (rs6152, rs1204038, and rs1337082; r 2 >0.6) were associated with increased risk for endometrial cancer. The strongest association was observed for rs6152, with the odds ratios (95% confidence interval) being 1.13 (0.89-1.44) for heterozygous and 2.40 (1.28-4.51) for homozygous minor genotypes (P trend = 0.02) compared with homozygous major allele genotype. However, these associations were not statistically significant after permutation adjustment for multiple comparisons (P trend > 0.09). Haplotype analyses did not reveal any additional associations with endometrial cancer. Results from our study, taken together with previously published studies, provide little evidence of a consistent association between common genetic variation in AR and endometrial cancer risk.

Original languageEnglish (US)
Pages (from-to)585-589
Number of pages5
JournalCancer Epidemiology Biomarkers and Prevention
Volume18
Issue number2
DOIs
StatePublished - Feb 2009

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

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  • Cite this

    Yang, H. P., Garcia-Closas, M., Lacey, J. V., Brinton, L. A., Lissowska, J., Peplonska, B., Chanock, S., & Gaudet, M. M. (2009). Genetic variation in the androgen receptor gene and endometrial cancer risk. Cancer Epidemiology Biomarkers and Prevention, 18(2), 585-589. https://doi.org/10.1158/1055-9965.EPI-08-0677