Genetic variation in sodium-dependent vitamin C transporters SLC23A1 and SLC23A2 and risk of advanced colorectal adenoma

Hans Christian Erichsen, Ulrike Peters, Peter Eck, Robert Welch, Robert E. Schoen, Meredith Yeager, Mark Levine, Richard B. Hayes, Stephen Chanock

Research output: Contribution to journalArticle

Abstract

Previous observational studies suggest that vitamin C may reduce risk of colorectal cancer. Vitamin C transport is facilitated by membrane bound sodium-dependent transporters, SVCT1 (encoded by SLC23A1) and SVCT2 (encoded by SLC23A2). To investigate if common genetic variants in these two genes are associated with risk of colorectal tumor development, we conducted a case-control study of 656 Caucasian advanced distal colorectal adenoma cases and 665 Caucasian sigmoidoscopy-negative controls nested within the screening arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. The analysis of common single nucleotide polymorphisms in SLC23A1 revealed no association. For SLC23A2, overall, there was no association with haplotypes, but two SNPs located in intron 8 and exon 11 could be associated (odds ratio = 0.49, 95% confidence interval = 0.25-0.95 for haplotype G-C vs. haplotype C-C). The findings should be confirmed in follow-up studies, and further investigation is required to probe the functional basis of this finding.

Original languageEnglish (US)
Pages (from-to)652-659
Number of pages8
JournalNutrition and Cancer
Volume60
Issue number5
DOIs
StatePublished - Sep 2008

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Oncology
  • Nutrition and Dietetics
  • Cancer Research

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    Erichsen, H. C., Peters, U., Eck, P., Welch, R., Schoen, R. E., Yeager, M., Levine, M., Hayes, R. B., & Chanock, S. (2008). Genetic variation in sodium-dependent vitamin C transporters SLC23A1 and SLC23A2 and risk of advanced colorectal adenoma. Nutrition and Cancer, 60(5), 652-659. https://doi.org/10.1080/01635580802033110