Genetic variation in host defenses and viral infections

Eunhwa Choi, Stephen J. Chanock

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Conclusions: Recent advances in genomics now permit the analysis of germ-line variation and susceptibility to viral infections. So far, studies have investigated variation in genes of innate immunity, but it is clear that we must look at many pathways in host defenses. While the analysis of HLA, chemokines and cytokine defenses have been fruitful, the next steps require careful assessment of pathways to be analyzed because it is likely that sets of SNPs or haplotypes contribute to outcomes in viral infections. In conclusion, it is now possible to probe the genetic basis of host response to viral pathogens. Rapid progress in the technical and bioinformatic platforms has accelerated the opportunity to examine host-pathogen genomic interactions. Large epidemiological studies are required to adequately study common SNPs in case control or cohort studies addressing viral infections. Since SNP studies generally do identify a highly penetrant variant, follow-up validation studies are critical before implementation in medical care. It can be argued that no SNP study stands alone, but must be replicated to confirm the genetic link between one or more outcomes and the genetic variant(s) of interest.

Original languageEnglish (US)
Title of host publicationModulation of Host Gene Expression and Innate Immunity by Viruses
PublisherSpringer Netherlands
Pages281-294
Number of pages14
ISBN (Print)9781402032424, 1402032412, 9781402032417
DOIs
StatePublished - 2005
Externally publishedYes

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Virus Diseases
Single Nucleotide Polymorphism
Host-Pathogen Interactions
Validation Studies
Genomics
Computational Biology
Chemokines
Innate Immunity
Germ Cells
Haplotypes
Case-Control Studies
Epidemiologic Studies
Cohort Studies
Cytokines
Genes

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

Cite this

Choi, E., & Chanock, S. J. (2005). Genetic variation in host defenses and viral infections. In Modulation of Host Gene Expression and Innate Immunity by Viruses (pp. 281-294). Springer Netherlands. https://doi.org/10.1007/1-4020-3242-0_12

Genetic variation in host defenses and viral infections. / Choi, Eunhwa; Chanock, Stephen J.

Modulation of Host Gene Expression and Innate Immunity by Viruses. Springer Netherlands, 2005. p. 281-294.

Research output: Chapter in Book/Report/Conference proceedingChapter

Choi, E & Chanock, SJ 2005, Genetic variation in host defenses and viral infections. in Modulation of Host Gene Expression and Innate Immunity by Viruses. Springer Netherlands, pp. 281-294. https://doi.org/10.1007/1-4020-3242-0_12
Choi E, Chanock SJ. Genetic variation in host defenses and viral infections. In Modulation of Host Gene Expression and Innate Immunity by Viruses. Springer Netherlands. 2005. p. 281-294 https://doi.org/10.1007/1-4020-3242-0_12
Choi, Eunhwa ; Chanock, Stephen J. / Genetic variation in host defenses and viral infections. Modulation of Host Gene Expression and Innate Immunity by Viruses. Springer Netherlands, 2005. pp. 281-294
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