Genetic variation at the synaptic vesicle gene SV2A is associated with schizophrenia

Manuel Mattheisen, Thomas W. Mühleisen, Jana Strohmaier, Jens Treutlein, Igor Nenadic, Margrieta Alblas, Sandra Meier, Franziska Degenhardt, Stefan Herms, Per Hoffmann, Stephanie H. Witt, Ina Giegling, Heinrich Sauer, Thomas G. Schulze, Dan Rujescu, Markus M. Nöthen, Marcella Rietschel, Sven Cichon

Research output: Contribution to journalArticle

Abstract

Convergent evidence from pharmacological and animal studies suggests a possible role for the synaptic vesicle glycoprotein 2A gene (. SV2A) in schizophrenia susceptibility. To test systematically all common variants in the SV2A gene region for an association with schizophrenia, we used a HapMap-based haplotype tagging approach and tested five SNPs in 794 patients and 843 controls. The SNP rs15931 showed evidence for an association with schizophrenia and was followed-up in an independent sample of 2581 individuals (overall p-value. =. 0.0042, OR. =. 0.779). Our study in the German population provides evidence, at a genetic level, for the involvement of the SV2A gene region in schizophrenia.

Original languageEnglish (US)
Pages (from-to)262-265
Number of pages4
JournalSchizophrenia Research
Volume141
Issue number2-3
DOIs
StatePublished - Nov 2012
Externally publishedYes

Keywords

  • Candidate gene
  • GABA
  • Neuropsychiatric disorder
  • Single-nucleotide polymorphism
  • Synapse

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Fingerprint Dive into the research topics of 'Genetic variation at the synaptic vesicle gene SV2A is associated with schizophrenia'. Together they form a unique fingerprint.

  • Cite this

    Mattheisen, M., Mühleisen, T. W., Strohmaier, J., Treutlein, J., Nenadic, I., Alblas, M., Meier, S., Degenhardt, F., Herms, S., Hoffmann, P., Witt, S. H., Giegling, I., Sauer, H., Schulze, T. G., Rujescu, D., Nöthen, M. M., Rietschel, M., & Cichon, S. (2012). Genetic variation at the synaptic vesicle gene SV2A is associated with schizophrenia. Schizophrenia Research, 141(2-3), 262-265. https://doi.org/10.1016/j.schres.2012.08.027