Genetic variation at the synaptic vesicle gene SV2A is associated with schizophrenia

Manuel Mattheisen; Thomas W. Mühleisen; Jana Strohmaier; Jens Treutlein; Igor Nenadic; Margrieta Alblas; Sandra Meier; Franziska Degenhardt; Stefan Herms; Per Hoffmann; Stephanie H. Witt; Ina Giegling; Heinrich Sauer; Thomas G. Schulze; Dan Rujescu; Markus M. Nöthen; Marcella Rietschel; Sven Cichon

doi:10.1016/j.schres.2012.08.027

Genetic variation at the synaptic vesicle gene SV2A is associated with schizophrenia

Manuel Mattheisen, Thomas W. Mühleisen, Jana Strohmaier, Jens Treutlein, Igor Nenadic, Margrieta Alblas, Sandra Meier, Franziska Degenhardt, Stefan Herms, Per Hoffmann, Stephanie H. Witt, Ina Giegling, Heinrich Sauer, Thomas G. Schulze, Dan Rujescu, Markus M. Nöthen, Marcella Rietschel, Sven Cichon

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Convergent evidence from pharmacological and animal studies suggests a possible role for the synaptic vesicle glycoprotein 2A gene (. SV2A) in schizophrenia susceptibility. To test systematically all common variants in the SV2A gene region for an association with schizophrenia, we used a HapMap-based haplotype tagging approach and tested five SNPs in 794 patients and 843 controls. The SNP rs15931 showed evidence for an association with schizophrenia and was followed-up in an independent sample of 2581 individuals (overall p-value. =. 0.0042, OR. =. 0.779). Our study in the German population provides evidence, at a genetic level, for the involvement of the SV2A gene region in schizophrenia.

Original language	English (US)
Pages (from-to)	262-265
Number of pages	4
Journal	Schizophrenia Research
Volume	141
Issue number	2-3
DOIs	https://doi.org/10.1016/j.schres.2012.08.027
State	Published - Nov 2012
Externally published	Yes

Keywords

Candidate gene
GABA
Neuropsychiatric disorder
Single-nucleotide polymorphism
Synapse

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/j.schres.2012.08.027

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Mattheisen, M., Mühleisen, T. W., Strohmaier, J., Treutlein, J., Nenadic, I., Alblas, M., Meier, S., Degenhardt, F., Herms, S., Hoffmann, P., Witt, S. H., Giegling, I., Sauer, H., Schulze, T. G., Rujescu, D., Nöthen, M. M., Rietschel, M., & Cichon, S. (2012). Genetic variation at the synaptic vesicle gene SV2A is associated with schizophrenia. Schizophrenia Research, 141(2-3), 262-265. https://doi.org/10.1016/j.schres.2012.08.027

Mattheisen, M, Mühleisen, TW, Strohmaier, J, Treutlein, J, Nenadic, I, Alblas, M, Meier, S, Degenhardt, F, Herms, S, Hoffmann, P, Witt, SH, Giegling, I, Sauer, H, Schulze, TG, Rujescu, D, Nöthen, MM, Rietschel, M & Cichon, S 2012, 'Genetic variation at the synaptic vesicle gene SV2A is associated with schizophrenia', Schizophrenia Research, vol. 141, no. 2-3, pp. 262-265. https://doi.org/10.1016/j.schres.2012.08.027

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title = "Genetic variation at the synaptic vesicle gene SV2A is associated with schizophrenia",

abstract = "Convergent evidence from pharmacological and animal studies suggests a possible role for the synaptic vesicle glycoprotein 2A gene (. SV2A) in schizophrenia susceptibility. To test systematically all common variants in the SV2A gene region for an association with schizophrenia, we used a HapMap-based haplotype tagging approach and tested five SNPs in 794 patients and 843 controls. The SNP rs15931 showed evidence for an association with schizophrenia and was followed-up in an independent sample of 2581 individuals (overall p-value. =. 0.0042, OR. =. 0.779). Our study in the German population provides evidence, at a genetic level, for the involvement of the SV2A gene region in schizophrenia.",

keywords = "Candidate gene, GABA, Neuropsychiatric disorder, Single-nucleotide polymorphism, Synapse",

author = "Manuel Mattheisen and M{\"u}hleisen, {Thomas W.} and Jana Strohmaier and Jens Treutlein and Igor Nenadic and Margrieta Alblas and Sandra Meier and Franziska Degenhardt and Stefan Herms and Per Hoffmann and Witt, {Stephanie H.} and Ina Giegling and Heinrich Sauer and Schulze, {Thomas G.} and Dan Rujescu and N{\"o}then, {Markus M.} and Marcella Rietschel and Sven Cichon",

year = "2012",

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doi = "10.1016/j.schres.2012.08.027",

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AU - Mühleisen, Thomas W.

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AU - Nenadic, Igor

AU - Alblas, Margrieta

AU - Meier, Sandra

AU - Degenhardt, Franziska

AU - Herms, Stefan

AU - Hoffmann, Per

AU - Witt, Stephanie H.

AU - Giegling, Ina

AU - Sauer, Heinrich

AU - Schulze, Thomas G.

AU - Rujescu, Dan

AU - Nöthen, Markus M.

AU - Rietschel, Marcella

AU - Cichon, Sven

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AB - Convergent evidence from pharmacological and animal studies suggests a possible role for the synaptic vesicle glycoprotein 2A gene (. SV2A) in schizophrenia susceptibility. To test systematically all common variants in the SV2A gene region for an association with schizophrenia, we used a HapMap-based haplotype tagging approach and tested five SNPs in 794 patients and 843 controls. The SNP rs15931 showed evidence for an association with schizophrenia and was followed-up in an independent sample of 2581 individuals (overall p-value. =. 0.0042, OR. =. 0.779). Our study in the German population provides evidence, at a genetic level, for the involvement of the SV2A gene region in schizophrenia.

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KW - GABA

KW - Neuropsychiatric disorder

KW - Single-nucleotide polymorphism

KW - Synapse

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Genetic variation at the synaptic vesicle gene SV2A is associated with schizophrenia

Abstract

Keywords

ASJC Scopus subject areas

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