TY - JOUR
T1 - Genetic variation at the synaptic vesicle gene SV2A is associated with schizophrenia
AU - Mattheisen, Manuel
AU - Mühleisen, Thomas W.
AU - Strohmaier, Jana
AU - Treutlein, Jens
AU - Nenadic, Igor
AU - Alblas, Margrieta
AU - Meier, Sandra
AU - Degenhardt, Franziska
AU - Herms, Stefan
AU - Hoffmann, Per
AU - Witt, Stephanie H.
AU - Giegling, Ina
AU - Sauer, Heinrich
AU - Schulze, Thomas G.
AU - Rujescu, Dan
AU - Nöthen, Markus M.
AU - Rietschel, Marcella
AU - Cichon, Sven
PY - 2012/11
Y1 - 2012/11
N2 - Convergent evidence from pharmacological and animal studies suggests a possible role for the synaptic vesicle glycoprotein 2A gene (. SV2A) in schizophrenia susceptibility. To test systematically all common variants in the SV2A gene region for an association with schizophrenia, we used a HapMap-based haplotype tagging approach and tested five SNPs in 794 patients and 843 controls. The SNP rs15931 showed evidence for an association with schizophrenia and was followed-up in an independent sample of 2581 individuals (overall p-value. =. 0.0042, OR. =. 0.779). Our study in the German population provides evidence, at a genetic level, for the involvement of the SV2A gene region in schizophrenia.
AB - Convergent evidence from pharmacological and animal studies suggests a possible role for the synaptic vesicle glycoprotein 2A gene (. SV2A) in schizophrenia susceptibility. To test systematically all common variants in the SV2A gene region for an association with schizophrenia, we used a HapMap-based haplotype tagging approach and tested five SNPs in 794 patients and 843 controls. The SNP rs15931 showed evidence for an association with schizophrenia and was followed-up in an independent sample of 2581 individuals (overall p-value. =. 0.0042, OR. =. 0.779). Our study in the German population provides evidence, at a genetic level, for the involvement of the SV2A gene region in schizophrenia.
KW - Candidate gene
KW - GABA
KW - Neuropsychiatric disorder
KW - Single-nucleotide polymorphism
KW - Synapse
UR - http://www.scopus.com/inward/record.url?scp=84866907367&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84866907367&partnerID=8YFLogxK
U2 - 10.1016/j.schres.2012.08.027
DO - 10.1016/j.schres.2012.08.027
M3 - Article
C2 - 23017826
AN - SCOPUS:84866907367
SN - 0920-9964
VL - 141
SP - 262
EP - 265
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 2-3
ER -