Genetic variation and hematopoietic stem cell transplantation: Expansion of the paradigm

Sharon A. Savage, Stephen Chanock

Research output: Contribution to journalArticle

Abstract

Genetic variation has been the mainstay of hematopoietic stem cell transplantation since the first transplants were attempted. A significant expansion of genetic knowledge is under way, as the draft sequence of the human genome is annotated. Hematopoietic stem cell transplantation is a field that will greatly benefit from this new knowledge, but the manner in which it is applied is daunting. Variation within key molecules related to hematopoietic stem cell transplant in combination with the current knowledge of human leukocyte antigen variation will serve to improve donor-recipient matches and clinical outcome.

Original languageEnglish (US)
Pages (from-to)32-39
Number of pages8
JournalPediatric Transplantation
Volume7
Issue numberSUPPL. 3
DOIs
StatePublished - 2003
Externally publishedYes

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Hematopoietic Stem Cell Transplantation
Transplants
Antigenic Variation
Human Genome
HLA Antigens
Hematopoietic Stem Cells

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Transplantation

Cite this

Genetic variation and hematopoietic stem cell transplantation : Expansion of the paradigm. / Savage, Sharon A.; Chanock, Stephen.

In: Pediatric Transplantation, Vol. 7, No. SUPPL. 3, 2003, p. 32-39.

Research output: Contribution to journalArticle

Savage, Sharon A. ; Chanock, Stephen. / Genetic variation and hematopoietic stem cell transplantation : Expansion of the paradigm. In: Pediatric Transplantation. 2003 ; Vol. 7, No. SUPPL. 3. pp. 32-39.
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