Genetic variants of the T-cell immunoglobulin mucin 1 but not the T-cell immunoglobulin mucin 3 gene are associated with asthma in an African American population

Peisong Gao, Rasika Mathias, Beverly Plunkett, Alkis Togias, Kathleen C. Barnes, Terri L Beaty, Shau Ku Huang

Research output: Contribution to journalArticle

Abstract

Background: The T-cell immunoglobulin mucin (TIM) proteins and their genetic variants have been suggested to play a role in regulating allergic diseases. Objective: Genetic association of the sequence variants for TIM-1 and TIM-3 genes with asthma in an African American population was investigated. Methods: Both case-control and family-based association analyses were performed for a total of 7 polymorphisms, including 3 single nucleotide polymorphism (SNPs) and 1 insertion/deletion polymorphism in the TIM-1 and 3 SNPs in the TIM-3 genes. The exposure to hepatitis A virus as judged by seropositivity was also examined. Results: In the case-control design, the frequencies of the TT genotype for SNP rs2277025 and the homozygous deletion variant (157delMTTTVP) in the fourth exon of the TIM-1 gene were higher among patients with patients with asthma compared with the controls (odds ratio [OR], 2.779, P =. 016; and OR, 3.09, P =. 022, respectively). This association was substantiated by haplotype analysis of these and 2 additional SNPs (OR, 2.48; P =. 004), and also by family-based tests for the allele and haplotype carrying 157delMTTTVP (P =. 009 and P =. 048, respectively). Furthermore, this association seems to exist even in the hepatitis A virus-seronegative subjects in our data. None of the 3 variants in TIM-3 genes yielded significant association with either asthma or asthma-related phenotypes. Conclusion: Our findings suggest that the genetic variants of the TIM-1 but not the TIM-3 gene contribute to asthma susceptibility in this African-American population.

Original languageEnglish (US)
Pages (from-to)982-988
Number of pages7
JournalThe Journal of Allergy and Clinical Immunology
Volume115
Issue number5
DOIs
StatePublished - May 2005

Fingerprint

Mucin-3
Mucin-1
African Americans
Immunoglobulins
Asthma
T-Lymphocytes
Population
Genes
Single Nucleotide Polymorphism
Hepatitis A virus
Odds Ratio
Haplotypes
Mucins
Exons

Keywords

  • Asthma
  • Haplotype
  • Hepatitis A
  • Single nucleotide polymorphism
  • T-cell immunoglobulin mucin

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Genetic variants of the T-cell immunoglobulin mucin 1 but not the T-cell immunoglobulin mucin 3 gene are associated with asthma in an African American population. / Gao, Peisong; Mathias, Rasika; Plunkett, Beverly; Togias, Alkis; Barnes, Kathleen C.; Beaty, Terri L; Huang, Shau Ku.

In: The Journal of Allergy and Clinical Immunology, Vol. 115, No. 5, 05.2005, p. 982-988.

Research output: Contribution to journalArticle

@article{b378a640e48547c6bb0f0d1d407e6a5f,
title = "Genetic variants of the T-cell immunoglobulin mucin 1 but not the T-cell immunoglobulin mucin 3 gene are associated with asthma in an African American population",
abstract = "Background: The T-cell immunoglobulin mucin (TIM) proteins and their genetic variants have been suggested to play a role in regulating allergic diseases. Objective: Genetic association of the sequence variants for TIM-1 and TIM-3 genes with asthma in an African American population was investigated. Methods: Both case-control and family-based association analyses were performed for a total of 7 polymorphisms, including 3 single nucleotide polymorphism (SNPs) and 1 insertion/deletion polymorphism in the TIM-1 and 3 SNPs in the TIM-3 genes. The exposure to hepatitis A virus as judged by seropositivity was also examined. Results: In the case-control design, the frequencies of the TT genotype for SNP rs2277025 and the homozygous deletion variant (157delMTTTVP) in the fourth exon of the TIM-1 gene were higher among patients with patients with asthma compared with the controls (odds ratio [OR], 2.779, P =. 016; and OR, 3.09, P =. 022, respectively). This association was substantiated by haplotype analysis of these and 2 additional SNPs (OR, 2.48; P =. 004), and also by family-based tests for the allele and haplotype carrying 157delMTTTVP (P =. 009 and P =. 048, respectively). Furthermore, this association seems to exist even in the hepatitis A virus-seronegative subjects in our data. None of the 3 variants in TIM-3 genes yielded significant association with either asthma or asthma-related phenotypes. Conclusion: Our findings suggest that the genetic variants of the TIM-1 but not the TIM-3 gene contribute to asthma susceptibility in this African-American population.",
keywords = "Asthma, Haplotype, Hepatitis A, Single nucleotide polymorphism, T-cell immunoglobulin mucin",
author = "Peisong Gao and Rasika Mathias and Beverly Plunkett and Alkis Togias and Barnes, {Kathleen C.} and Beaty, {Terri L} and Huang, {Shau Ku}",
year = "2005",
month = "5",
doi = "10.1016/j.jaci.2005.01.035",
language = "English (US)",
volume = "115",
pages = "982--988",
journal = "Journal of Allergy and Clinical Immunology",
issn = "0091-6749",
publisher = "Mosby Inc.",
number = "5",

}

TY - JOUR

T1 - Genetic variants of the T-cell immunoglobulin mucin 1 but not the T-cell immunoglobulin mucin 3 gene are associated with asthma in an African American population

AU - Gao, Peisong

AU - Mathias, Rasika

AU - Plunkett, Beverly

AU - Togias, Alkis

AU - Barnes, Kathleen C.

AU - Beaty, Terri L

AU - Huang, Shau Ku

PY - 2005/5

Y1 - 2005/5

N2 - Background: The T-cell immunoglobulin mucin (TIM) proteins and their genetic variants have been suggested to play a role in regulating allergic diseases. Objective: Genetic association of the sequence variants for TIM-1 and TIM-3 genes with asthma in an African American population was investigated. Methods: Both case-control and family-based association analyses were performed for a total of 7 polymorphisms, including 3 single nucleotide polymorphism (SNPs) and 1 insertion/deletion polymorphism in the TIM-1 and 3 SNPs in the TIM-3 genes. The exposure to hepatitis A virus as judged by seropositivity was also examined. Results: In the case-control design, the frequencies of the TT genotype for SNP rs2277025 and the homozygous deletion variant (157delMTTTVP) in the fourth exon of the TIM-1 gene were higher among patients with patients with asthma compared with the controls (odds ratio [OR], 2.779, P =. 016; and OR, 3.09, P =. 022, respectively). This association was substantiated by haplotype analysis of these and 2 additional SNPs (OR, 2.48; P =. 004), and also by family-based tests for the allele and haplotype carrying 157delMTTTVP (P =. 009 and P =. 048, respectively). Furthermore, this association seems to exist even in the hepatitis A virus-seronegative subjects in our data. None of the 3 variants in TIM-3 genes yielded significant association with either asthma or asthma-related phenotypes. Conclusion: Our findings suggest that the genetic variants of the TIM-1 but not the TIM-3 gene contribute to asthma susceptibility in this African-American population.

AB - Background: The T-cell immunoglobulin mucin (TIM) proteins and their genetic variants have been suggested to play a role in regulating allergic diseases. Objective: Genetic association of the sequence variants for TIM-1 and TIM-3 genes with asthma in an African American population was investigated. Methods: Both case-control and family-based association analyses were performed for a total of 7 polymorphisms, including 3 single nucleotide polymorphism (SNPs) and 1 insertion/deletion polymorphism in the TIM-1 and 3 SNPs in the TIM-3 genes. The exposure to hepatitis A virus as judged by seropositivity was also examined. Results: In the case-control design, the frequencies of the TT genotype for SNP rs2277025 and the homozygous deletion variant (157delMTTTVP) in the fourth exon of the TIM-1 gene were higher among patients with patients with asthma compared with the controls (odds ratio [OR], 2.779, P =. 016; and OR, 3.09, P =. 022, respectively). This association was substantiated by haplotype analysis of these and 2 additional SNPs (OR, 2.48; P =. 004), and also by family-based tests for the allele and haplotype carrying 157delMTTTVP (P =. 009 and P =. 048, respectively). Furthermore, this association seems to exist even in the hepatitis A virus-seronegative subjects in our data. None of the 3 variants in TIM-3 genes yielded significant association with either asthma or asthma-related phenotypes. Conclusion: Our findings suggest that the genetic variants of the TIM-1 but not the TIM-3 gene contribute to asthma susceptibility in this African-American population.

KW - Asthma

KW - Haplotype

KW - Hepatitis A

KW - Single nucleotide polymorphism

KW - T-cell immunoglobulin mucin

UR - http://www.scopus.com/inward/record.url?scp=18144366600&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=18144366600&partnerID=8YFLogxK

U2 - 10.1016/j.jaci.2005.01.035

DO - 10.1016/j.jaci.2005.01.035

M3 - Article

C2 - 15867855

AN - SCOPUS:18144366600

VL - 115

SP - 982

EP - 988

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

SN - 0091-6749

IS - 5

ER -