Genetic variants in the mannose receptor gene (MRC1) are associated with asthma in two independent populations

Takeshi Hattori; Satoshi Konno; Nobuyuki Hizawa; Akira Isada; Ayumu Takahashi; Kaoruko Shimizu; Kenichi Shimizu; Peisong Gao; Terri H. Beaty; Kathleen C. Barnes; Shau Ku Huang; Masaharu Nishimura

doi:10.1007/s00251-009-0403-x

Genetic variants in the mannose receptor gene (MRC1) are associated with asthma in two independent populations

Takeshi Hattori, Satoshi Konno, Nobuyuki Hizawa, Akira Isada, Ayumu Takahashi, Kaoruko Shimizu, Kenichi Shimizu, Peisong Gao, Terri H. Beaty, Kathleen C. Barnes, Shau Ku Huang, Masaharu Nishimura

School of Medicine

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Mannose receptor is a member of the C-type lectin receptor family involved in pathogen molecular pattern recognition and thought to be critical in shaping host immune responses and maintaining homeostasis. The aim of this study was to investigate potential associations of genetic variants in the MRC1 gene with asthma in two independent populations. Seven single-nucleotide polymorphisms (SNPs; rs2477637, rs2253120, rs2477631, rs2477664, rs692527, rs1926736, and rs691005) in the MRC1 gene locus were genotyped and evaluated regarding association with asthma in 870 unrelated Japanese subjects (446 asthmatics, 424 controls). The same markers were validated in 176 unrelated African-American subjects (86 asthmatics, 90 controls). Suggestive evidence of association between five SNPs (rs2477637, rs2253120, rs2477664, rs692527, and rs1926736) and asthma was observed in the analysis of the Japanese population independent of sex, age, smoking status, and atopic status. SNPs rs692527 and rs691005 showed significant association with asthma in the African-American population. Haplotypes containing two linked SNPs (rs692527 and rs1926736) were significantly associated with asthma in both Japanese and African-American populations. Our results suggest that sequence variations in the MRC1 gene are associated with the development of asthma in two independent and ethnically diverse populations.

Original language	English (US)
Pages (from-to)	731-738
Number of pages	8
Journal	Immunogenetics
Volume	61
Issue number	11-12
DOIs	https://doi.org/10.1007/s00251-009-0403-x
State	Published - Dec 2009

Keywords

Bronchial asthma
Innate immunity
MRC1 gene
Mannose receptor
Polymorphism

ASJC Scopus subject areas

Immunology
Genetics

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10.1007/s00251-009-0403-x

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@article{a6fca959a6c4415c99fa5e4a2fdc3be8,

title = "Genetic variants in the mannose receptor gene (MRC1) are associated with asthma in two independent populations",

abstract = "Mannose receptor is a member of the C-type lectin receptor family involved in pathogen molecular pattern recognition and thought to be critical in shaping host immune responses and maintaining homeostasis. The aim of this study was to investigate potential associations of genetic variants in the MRC1 gene with asthma in two independent populations. Seven single-nucleotide polymorphisms (SNPs; rs2477637, rs2253120, rs2477631, rs2477664, rs692527, rs1926736, and rs691005) in the MRC1 gene locus were genotyped and evaluated regarding association with asthma in 870 unrelated Japanese subjects (446 asthmatics, 424 controls). The same markers were validated in 176 unrelated African-American subjects (86 asthmatics, 90 controls). Suggestive evidence of association between five SNPs (rs2477637, rs2253120, rs2477664, rs692527, and rs1926736) and asthma was observed in the analysis of the Japanese population independent of sex, age, smoking status, and atopic status. SNPs rs692527 and rs691005 showed significant association with asthma in the African-American population. Haplotypes containing two linked SNPs (rs692527 and rs1926736) were significantly associated with asthma in both Japanese and African-American populations. Our results suggest that sequence variations in the MRC1 gene are associated with the development of asthma in two independent and ethnically diverse populations.",

keywords = "Bronchial asthma, Innate immunity, MRC1 gene, Mannose receptor, Polymorphism",

author = "Takeshi Hattori and Satoshi Konno and Nobuyuki Hizawa and Akira Isada and Ayumu Takahashi and Kaoruko Shimizu and Kenichi Shimizu and Peisong Gao and Beaty, {Terri H.} and Barnes, {Kathleen C.} and Huang, {Shau Ku} and Masaharu Nishimura",

note = "Funding Information: Acknowledgements We thank all the volunteers who graciously agreed to participate in this study. We wish to thank CSGA investigators Georgia Dunston and Alkis Togias for phenotyping assistance. This work was supported by the National Institutes of Health grants U01 HL/AI-49612 (to THB) and RO1 AI-052468 (to SKH). K.C.B. was supported in part by the Mary Beryl Patch Turnbull Scholar Program.",

year = "2009",

month = dec,

doi = "10.1007/s00251-009-0403-x",

language = "English (US)",

volume = "61",

pages = "731--738",

journal = "Immunogenetics",

issn = "0093-7711",

publisher = "Springer Verlag",

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TY - JOUR

T1 - Genetic variants in the mannose receptor gene (MRC1) are associated with asthma in two independent populations

AU - Hattori, Takeshi

AU - Konno, Satoshi

AU - Hizawa, Nobuyuki

AU - Isada, Akira

AU - Takahashi, Ayumu

AU - Shimizu, Kaoruko

AU - Shimizu, Kenichi

AU - Gao, Peisong

AU - Beaty, Terri H.

AU - Barnes, Kathleen C.

AU - Huang, Shau Ku

AU - Nishimura, Masaharu

N1 - Funding Information: Acknowledgements We thank all the volunteers who graciously agreed to participate in this study. We wish to thank CSGA investigators Georgia Dunston and Alkis Togias for phenotyping assistance. This work was supported by the National Institutes of Health grants U01 HL/AI-49612 (to THB) and RO1 AI-052468 (to SKH). K.C.B. was supported in part by the Mary Beryl Patch Turnbull Scholar Program.

PY - 2009/12

Y1 - 2009/12

N2 - Mannose receptor is a member of the C-type lectin receptor family involved in pathogen molecular pattern recognition and thought to be critical in shaping host immune responses and maintaining homeostasis. The aim of this study was to investigate potential associations of genetic variants in the MRC1 gene with asthma in two independent populations. Seven single-nucleotide polymorphisms (SNPs; rs2477637, rs2253120, rs2477631, rs2477664, rs692527, rs1926736, and rs691005) in the MRC1 gene locus were genotyped and evaluated regarding association with asthma in 870 unrelated Japanese subjects (446 asthmatics, 424 controls). The same markers were validated in 176 unrelated African-American subjects (86 asthmatics, 90 controls). Suggestive evidence of association between five SNPs (rs2477637, rs2253120, rs2477664, rs692527, and rs1926736) and asthma was observed in the analysis of the Japanese population independent of sex, age, smoking status, and atopic status. SNPs rs692527 and rs691005 showed significant association with asthma in the African-American population. Haplotypes containing two linked SNPs (rs692527 and rs1926736) were significantly associated with asthma in both Japanese and African-American populations. Our results suggest that sequence variations in the MRC1 gene are associated with the development of asthma in two independent and ethnically diverse populations.

AB - Mannose receptor is a member of the C-type lectin receptor family involved in pathogen molecular pattern recognition and thought to be critical in shaping host immune responses and maintaining homeostasis. The aim of this study was to investigate potential associations of genetic variants in the MRC1 gene with asthma in two independent populations. Seven single-nucleotide polymorphisms (SNPs; rs2477637, rs2253120, rs2477631, rs2477664, rs692527, rs1926736, and rs691005) in the MRC1 gene locus were genotyped and evaluated regarding association with asthma in 870 unrelated Japanese subjects (446 asthmatics, 424 controls). The same markers were validated in 176 unrelated African-American subjects (86 asthmatics, 90 controls). Suggestive evidence of association between five SNPs (rs2477637, rs2253120, rs2477664, rs692527, and rs1926736) and asthma was observed in the analysis of the Japanese population independent of sex, age, smoking status, and atopic status. SNPs rs692527 and rs691005 showed significant association with asthma in the African-American population. Haplotypes containing two linked SNPs (rs692527 and rs1926736) were significantly associated with asthma in both Japanese and African-American populations. Our results suggest that sequence variations in the MRC1 gene are associated with the development of asthma in two independent and ethnically diverse populations.

KW - Bronchial asthma

KW - Innate immunity

KW - MRC1 gene

KW - Mannose receptor

KW - Polymorphism

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U2 - 10.1007/s00251-009-0403-x

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AN - SCOPUS:73949097953

SN - 0093-7711

VL - 61

SP - 731

EP - 738

JO - Immunogenetics

JF - Immunogenetics

IS - 11-12

ER -

Genetic variants in the mannose receptor gene (MRC1) are associated with asthma in two independent populations

Abstract

Keywords

ASJC Scopus subject areas

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