Genetic variants in frizzled-related protein (FRZB) and the risk of colorectal neoplasia

Sonja I. Berndt, Wen Yi Huang, Meredith Yeager, Joel L. Weissfeld, Stephen J. Chanock, Richard B. Hayes

Research output: Contribution to journalArticle

Abstract

Objective: The Wnt/APC/β-catenin signaling pathway, which includes frizzled-related protein (FRZB), plays a critical role in the development of colorectal cancer, and recent evidence suggests that the functional polymorphism, FRZB Arg324Gly, may be associated with risk for this disease. To determine if this finding could be replicated, we investigated the association between two FRZB polymorphisms (Arg324Gly and Arg200Trp) and the risk of colorectal adenoma and cancer in nested case-control studies. Methods: Participants consisted of 1,709 adenoma cases, 620 cancer cases, and 1,849 controls within the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CI) for the associations with colorectal neoplasia. Results: No association was observed for either polymorphism or any haplotypes with colorectal adenoma or colorectal cancer (p > 0.05 for all). Conclusion: Our study does not support the previously observed association between the FRZB 324Gly variant and colorectal cancer risk. However, further study of additional genetic variants within this pathway is still warranted, given the important role of the Wnt signaling pathway in colorectal carcinogenesis.

Original languageEnglish (US)
Pages (from-to)487-490
Number of pages4
JournalCancer Causes and Control
Volume20
Issue number4
DOIs
StatePublished - May 2009
Externally publishedYes

Fingerprint

Colorectal Neoplasms
Adenoma
Neoplasms
Catenins
Wnt Signaling Pathway
Early Detection of Cancer
Ovarian Neoplasms
Haplotypes
Case-Control Studies
Lung Neoplasms
Prostatic Neoplasms
Carcinogenesis
Logistic Models
Odds Ratio
FRZB protein
Confidence Intervals

Keywords

  • Colorectal adenoma
  • Colorectal cancer
  • Polymorphism
  • Wnt signaling pathway

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Berndt, S. I., Huang, W. Y., Yeager, M., Weissfeld, J. L., Chanock, S. J., & Hayes, R. B. (2009). Genetic variants in frizzled-related protein (FRZB) and the risk of colorectal neoplasia. Cancer Causes and Control, 20(4), 487-490. https://doi.org/10.1007/s10552-008-9274-y

Genetic variants in frizzled-related protein (FRZB) and the risk of colorectal neoplasia. / Berndt, Sonja I.; Huang, Wen Yi; Yeager, Meredith; Weissfeld, Joel L.; Chanock, Stephen J.; Hayes, Richard B.

In: Cancer Causes and Control, Vol. 20, No. 4, 05.2009, p. 487-490.

Research output: Contribution to journalArticle

Berndt, SI, Huang, WY, Yeager, M, Weissfeld, JL, Chanock, SJ & Hayes, RB 2009, 'Genetic variants in frizzled-related protein (FRZB) and the risk of colorectal neoplasia', Cancer Causes and Control, vol. 20, no. 4, pp. 487-490. https://doi.org/10.1007/s10552-008-9274-y
Berndt, Sonja I. ; Huang, Wen Yi ; Yeager, Meredith ; Weissfeld, Joel L. ; Chanock, Stephen J. ; Hayes, Richard B. / Genetic variants in frizzled-related protein (FRZB) and the risk of colorectal neoplasia. In: Cancer Causes and Control. 2009 ; Vol. 20, No. 4. pp. 487-490.
@article{2d1cf141a3c64414b05efc048d649f46,
title = "Genetic variants in frizzled-related protein (FRZB) and the risk of colorectal neoplasia",
abstract = "Objective: The Wnt/APC/β-catenin signaling pathway, which includes frizzled-related protein (FRZB), plays a critical role in the development of colorectal cancer, and recent evidence suggests that the functional polymorphism, FRZB Arg324Gly, may be associated with risk for this disease. To determine if this finding could be replicated, we investigated the association between two FRZB polymorphisms (Arg324Gly and Arg200Trp) and the risk of colorectal adenoma and cancer in nested case-control studies. Methods: Participants consisted of 1,709 adenoma cases, 620 cancer cases, and 1,849 controls within the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial. Logistic regression was used to estimate odds ratios (ORs) and 95{\%} confidence intervals (95{\%} CI) for the associations with colorectal neoplasia. Results: No association was observed for either polymorphism or any haplotypes with colorectal adenoma or colorectal cancer (p > 0.05 for all). Conclusion: Our study does not support the previously observed association between the FRZB 324Gly variant and colorectal cancer risk. However, further study of additional genetic variants within this pathway is still warranted, given the important role of the Wnt signaling pathway in colorectal carcinogenesis.",
keywords = "Colorectal adenoma, Colorectal cancer, Polymorphism, Wnt signaling pathway",
author = "Berndt, {Sonja I.} and Huang, {Wen Yi} and Meredith Yeager and Weissfeld, {Joel L.} and Chanock, {Stephen J.} and Hayes, {Richard B.}",
year = "2009",
month = "5",
doi = "10.1007/s10552-008-9274-y",
language = "English (US)",
volume = "20",
pages = "487--490",
journal = "Cancer Causes and Control",
issn = "0957-5243",
publisher = "Springer Netherlands",
number = "4",

}

TY - JOUR

T1 - Genetic variants in frizzled-related protein (FRZB) and the risk of colorectal neoplasia

AU - Berndt, Sonja I.

AU - Huang, Wen Yi

AU - Yeager, Meredith

AU - Weissfeld, Joel L.

AU - Chanock, Stephen J.

AU - Hayes, Richard B.

PY - 2009/5

Y1 - 2009/5

N2 - Objective: The Wnt/APC/β-catenin signaling pathway, which includes frizzled-related protein (FRZB), plays a critical role in the development of colorectal cancer, and recent evidence suggests that the functional polymorphism, FRZB Arg324Gly, may be associated with risk for this disease. To determine if this finding could be replicated, we investigated the association between two FRZB polymorphisms (Arg324Gly and Arg200Trp) and the risk of colorectal adenoma and cancer in nested case-control studies. Methods: Participants consisted of 1,709 adenoma cases, 620 cancer cases, and 1,849 controls within the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CI) for the associations with colorectal neoplasia. Results: No association was observed for either polymorphism or any haplotypes with colorectal adenoma or colorectal cancer (p > 0.05 for all). Conclusion: Our study does not support the previously observed association between the FRZB 324Gly variant and colorectal cancer risk. However, further study of additional genetic variants within this pathway is still warranted, given the important role of the Wnt signaling pathway in colorectal carcinogenesis.

AB - Objective: The Wnt/APC/β-catenin signaling pathway, which includes frizzled-related protein (FRZB), plays a critical role in the development of colorectal cancer, and recent evidence suggests that the functional polymorphism, FRZB Arg324Gly, may be associated with risk for this disease. To determine if this finding could be replicated, we investigated the association between two FRZB polymorphisms (Arg324Gly and Arg200Trp) and the risk of colorectal adenoma and cancer in nested case-control studies. Methods: Participants consisted of 1,709 adenoma cases, 620 cancer cases, and 1,849 controls within the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CI) for the associations with colorectal neoplasia. Results: No association was observed for either polymorphism or any haplotypes with colorectal adenoma or colorectal cancer (p > 0.05 for all). Conclusion: Our study does not support the previously observed association between the FRZB 324Gly variant and colorectal cancer risk. However, further study of additional genetic variants within this pathway is still warranted, given the important role of the Wnt signaling pathway in colorectal carcinogenesis.

KW - Colorectal adenoma

KW - Colorectal cancer

KW - Polymorphism

KW - Wnt signaling pathway

UR - http://www.scopus.com/inward/record.url?scp=64649100458&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=64649100458&partnerID=8YFLogxK

U2 - 10.1007/s10552-008-9274-y

DO - 10.1007/s10552-008-9274-y

M3 - Article

C2 - 19067193

AN - SCOPUS:64649100458

VL - 20

SP - 487

EP - 490

JO - Cancer Causes and Control

JF - Cancer Causes and Control

SN - 0957-5243

IS - 4

ER -