Genetic variability of induction and emergence times for inhalational anaesthetics

S. Meier, H. Groeben, W. Mitzner, R. H. Brown

Research output: Contribution to journalArticle

Abstract

Background and objectives: Anaesthetic requirements differ among inbred mouse strains. We tested the genetic influence on induction and arousal times to inhalational anaesthetics in two of these strains. Methods: Five male C57BL/6J (B6) and five male C3H/HeJ (C3) mice were each exposed to five different concentrations of nitrous oxide (N2O) at five different levels of halothane. Time to sleep and arousal were assessed. Data were analysed by repeated measures of analysis of variance. Results: Halothane, N2O and genetic strain, all were significant independent factors on the time to sleep, while only N2O was a significant independent factor on the time to arousal (P = 0.004). B6 mice took significantly longer to fall asleep compared to the C3 mice controlling for halothane and N2O concentrations (F-ratio = 36, P < 0.0001). The effect of N2O on time to arousal was only significant for the B6 strain (F-ratio = 10, P = 0.005), and not for the C3 strain (F-ratio = 0.8, P = 0.38). Conclusions: Genetics influences the time to sleep for anaesthetic agents in mice.

Original languageEnglish (US)
Pages (from-to)113-117
Number of pages5
JournalEuropean Journal of Anaesthesiology
Volume25
Issue number2
DOIs
StatePublished - Feb 1 2008

Keywords

  • Anaesthesia, induction time, recovery time
  • Inbred Strains
  • Inhalational anaesthetics, halothane, nitrous oxide
  • Mice
  • Variation (Genetic)

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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