Genetic variability in inflammation pathways and prostate cancer risk

Jielin Sun, Aubrey Turner, Jianfeng Xu, Henrik Grönberg, William B Isaacs

Research output: Contribution to journalArticle

Abstract

Genetic susceptibility to prostate cancer has been consistently observed by a large number of studies. Recently, several pieces of evidence obtained from epidemiological and pathological studies support that chronic inflammation in prostate tissues may play a role in prostate cancer development. Multiple genes that play critical roles in inflammatory pathways have been associated with prostate cancer risk. In this article we review the key genetic findings of the associated genes. This includes 2 genes identified through family studies, ribonuclease L (RNASEL) and macrophage scavenger receptor 1 (MSR1), as well as a number of genes suggested by case-control studies, such as macrophage inhibitory cytokine-1 (MIC-1), interleukins (IL-8, IL-10), vascular endothelial growth factor (VEGF), intercellular adhesion molecule (ICAM), and Toll-like receptors (TLR-4, TLR-1-6-10 gene cluster). Overall, recent studies seem to suggest multiple genes work together to increase prostate risk, and this is consistent with the reality that inflammation is a very complex process. Thus, future studies are expected to place an emphasis on the study of gene-gene interactions. Advances in high throughput genotyping, data mining, and algorithm development are needed in order to produce interpretable results.

Original languageEnglish (US)
Pages (from-to)250-259
Number of pages10
JournalUrologic Oncology: Seminars and Original Investigations
Volume25
Issue number3
DOIs
StatePublished - May 2007

Fingerprint

Prostatic Neoplasms
Inflammation
Genes
Interleukin-8
Prostate
Growth Differentiation Factor 15
Scavenger Receptors
Toll-Like Receptor 4
Data Mining
Cell Adhesion Molecules
Genetic Predisposition to Disease
Ribonucleases
Multigene Family
Interleukin-10
Vascular Endothelial Growth Factor A
Case-Control Studies
Epidemiologic Studies

Keywords

  • Genetic variability
  • Inflammation
  • MSR1
  • Mutation
  • Prostate cancer
  • RNASEL
  • SNP
  • TLR

ASJC Scopus subject areas

  • Oncology
  • Urology

Cite this

Genetic variability in inflammation pathways and prostate cancer risk. / Sun, Jielin; Turner, Aubrey; Xu, Jianfeng; Grönberg, Henrik; Isaacs, William B.

In: Urologic Oncology: Seminars and Original Investigations, Vol. 25, No. 3, 05.2007, p. 250-259.

Research output: Contribution to journalArticle

Sun, Jielin ; Turner, Aubrey ; Xu, Jianfeng ; Grönberg, Henrik ; Isaacs, William B. / Genetic variability in inflammation pathways and prostate cancer risk. In: Urologic Oncology: Seminars and Original Investigations. 2007 ; Vol. 25, No. 3. pp. 250-259.
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