Genetic Understanding of OCD and Spectrum Disorders

Jack F. Samuels; Marco A. Grados; Elizabeth Planalp; O. Joseph Bienvenu

doi:10.1093/oxfordhb/9780195376210.013.0025

Genetic Understanding of OCD and Spectrum Disorders

Jack F. Samuels, Marco A. Grados, Elizabeth Planalp, O. Joseph Bienvenu

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

This chapter reviews the evidence for the genetic etiology of OCD and spectrum conditions. A genetic basis is supported by the familial aggregation of OCD; evidence for involvement of genes of major effect in segregation analyses; and higher concordance for OCD in identical than non-identical twins. Recent studies also support linkage of OCD to specific chromosomal regions and association of OCD with specific genetic polymorphisms. However, specific genes causing OCD have not yet been firmly established. The search for genes is complicated by the clinical and etiologic heterogeneity of OCD, as well as the possibility of gene-gene and gene-environmental interactions. Despite this complexity, developments in molecular and statistical genetics, and further refinement of the phenotype hold promise for further deepening our genetic understanding of OCD and spectrum disorders in the coming decade.

Original language	English (US)
Title of host publication	The Oxford Handbook of Obsessive Compulsive and Spectrum Disorders
Publisher	Oxford University Press
ISBN (Electronic)	9780199940561
ISBN (Print)	9780195376210
DOIs	https://doi.org/10.1093/oxfordhb/9780195376210.013.0025
State	Published - Sep 18 2012

Keywords

Candidate genes
Family studies
Genetic association
Genetic linkage
Genetics
Obsessive compulsive disorder
Twin studies

ASJC Scopus subject areas

Psychology(all)

Access to Document

10.1093/oxfordhb/9780195376210.013.0025

Cite this

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AU - Grados, Marco A.

AU - Planalp, Elizabeth

AU - Bienvenu, O. Joseph

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Genetic Understanding of OCD and Spectrum Disorders

Abstract

Keywords

ASJC Scopus subject areas

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