Genetic transformation of mosquitoes: A quest for malaria control

Luciano A. Moreira, Anil K. Ghosh, Eappen G. Abraham, Marcelo Jacobs-Lorena

Research output: Contribution to journalArticle

Abstract

Malaria inflicts an enormous toll in human lives and this burden is increasing. Present means to fight the disease, such as drugs and insecticides, are insufficient. Moreover, an effective vaccine has not yet been developed. This review examines an alternative strategy for malaria control, namely the genetic modification of mosquitoes to make them inefficient vectors for the parasite. The article summarises progress made toward the development of transposable element vectors for germ line transformation and the search for mosquito markers of transformation. Also reviewed is the search for anti-malarial effector genes whose products can inhibit development of the parasite in the mosquito with minimal fitness burden. While much progress has been made, much work remains to be done. Future research directions are discussed.

Original languageEnglish (US)
Pages (from-to)1599-1605
Number of pages7
JournalInternational Journal for Parasitology
Volume32
Issue number13
DOIs
StatePublished - Dec 4 2002

Keywords

  • Malaria
  • Mosquito transgenesis
  • Plasmodium
  • Refractory mosquitoes

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

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