TY - JOUR
T1 - Genetic transformation of mosquitoes
T2 - A quest for malaria control
AU - Moreira, Luciano A.
AU - Ghosh, Anil Kumar
AU - Abraham, Eappen G.
AU - Jacobs-Lorena, Marcelo
PY - 2002/12/4
Y1 - 2002/12/4
N2 - Malaria inflicts an enormous toll in human lives and this burden is increasing. Present means to fight the disease, such as drugs and insecticides, are insufficient. Moreover, an effective vaccine has not yet been developed. This review examines an alternative strategy for malaria control, namely the genetic modification of mosquitoes to make them inefficient vectors for the parasite. The article summarises progress made toward the development of transposable element vectors for germ line transformation and the search for mosquito markers of transformation. Also reviewed is the search for anti-malarial effector genes whose products can inhibit development of the parasite in the mosquito with minimal fitness burden. While much progress has been made, much work remains to be done. Future research directions are discussed.
AB - Malaria inflicts an enormous toll in human lives and this burden is increasing. Present means to fight the disease, such as drugs and insecticides, are insufficient. Moreover, an effective vaccine has not yet been developed. This review examines an alternative strategy for malaria control, namely the genetic modification of mosquitoes to make them inefficient vectors for the parasite. The article summarises progress made toward the development of transposable element vectors for germ line transformation and the search for mosquito markers of transformation. Also reviewed is the search for anti-malarial effector genes whose products can inhibit development of the parasite in the mosquito with minimal fitness burden. While much progress has been made, much work remains to be done. Future research directions are discussed.
KW - Malaria
KW - Mosquito transgenesis
KW - Plasmodium
KW - Refractory mosquitoes
UR - http://www.scopus.com/inward/record.url?scp=0037021385&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037021385&partnerID=8YFLogxK
U2 - 10.1016/S0020-7519(02)00188-1
DO - 10.1016/S0020-7519(02)00188-1
M3 - Article
C2 - 12435444
AN - SCOPUS:0037021385
SN - 0020-7519
VL - 32
SP - 1599
EP - 1605
JO - International Journal for Parasitology
JF - International Journal for Parasitology
IS - 13
ER -