Genetic Syndromes with Pancreatic Manifestations

Meredith E. Pittman, Lodewijk A A Brosens, Laura Delong Wood

Research output: Contribution to journalReview articlepeer-review

Abstract

Although the pancreas is affected by only a small fraction of known inherited disorders, several of these syndromes predispose patients to pancreatic adenocarcinoma, a cancer that has a consistently dismal prognosis. Still other syndromes are associated with neuroendocrine tumors, benign cysts, or recurrent pancreatitis. Because of the variability of pancreatic manifestations and outcomes, it is important for clinicians to be familiar with several well-described genetic disorders to ensure that patients are followed appropriately. The purpose of this review was to briefly describe the hereditary syndromes that are associated with pancreatic disorders and neoplasia.

Original languageEnglish (US)
Pages (from-to)705-715
Number of pages11
JournalSurgical Pathology Clinics
Volume9
Issue number4
DOIs
StatePublished - Dec 1 2016

Keywords

  • Familial syndromes
  • Genetics
  • Pancreatic cancer

ASJC Scopus subject areas

  • Surgery
  • Pathology and Forensic Medicine

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