Abstract
Four published genome screens have identified a number of markers with increased sharing in multiple sclerosis (MS) families, although none has reached statistical significance. One hundred and five markers previously identified as showing increased sharing in Canadian, British, Finnish, and American genome screens were genotyped in 219 sibling pairs ascertained from the database of the Canadian Collaborative Project on Genetic Susceptibility to MS (CCPGSMS). No markers examined met criteria for significant linkage. Markers located at 5p14 and 17q22 were analyzed in a total of 333 sibling pairs and attained mlod scores of 2.27 and 1.14, respectively. The known HLA Class II DRB1 association with MS was confirmed (P
| Original language | English (US) |
|---|---|
| Pages (from-to) | 145-151 |
| Number of pages | 7 |
| Journal | Neurogenetics |
| Volume | 3 |
| Issue number | 3 |
| DOIs | |
| State | Published - 2001 |
| Externally published | Yes |
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Keywords
- Linkage analysis
- Multiple sclerosis
- Susceptibility loci
ASJC Scopus subject areas
- Genetics(clinical)
- Neuroscience(all)
Cite this
Genetic susceptibility to MS : A second stage analysis in Canadian MS families. / Dyment, David A.; Willer, Cristen J.; Scott, Beverly; Armstrong, Holly; Ligers, Arturs; Hillert, Jan; Paty, Donald W.; Hashimoto, Stanley; Devonshire, Virginia; Hooge, John; Kastrukoff, Lorne; Oger, Joel; Metz, Luanne; Warren, Sharon; Hader, Walter; Power, Cristopher; Auty, Anthony; Nath, Avindra; Nelson, Robert; Freedman, Mark; Brunet, Donald; Paulseth, John E.; Rice, George; O'Connor, Paul; Duquette, Pierre; Lapierre, Yves; Francis, Gordon; Bouchard, Jean Pierre; Murray, T. John; Bhan, Virender; Maxner, Charles; Pryse-Phillips, William; Stefanelli, Mark; Sadovnick, A. Dessa; Risch, Neil; Ebers, George C.
In: Neurogenetics, Vol. 3, No. 3, 2001, p. 145-151.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Genetic susceptibility to MS
T2 - A second stage analysis in Canadian MS families
AU - Dyment, David A.
AU - Willer, Cristen J.
AU - Scott, Beverly
AU - Armstrong, Holly
AU - Ligers, Arturs
AU - Hillert, Jan
AU - Paty, Donald W.
AU - Hashimoto, Stanley
AU - Devonshire, Virginia
AU - Hooge, John
AU - Kastrukoff, Lorne
AU - Oger, Joel
AU - Metz, Luanne
AU - Warren, Sharon
AU - Hader, Walter
AU - Power, Cristopher
AU - Auty, Anthony
AU - Nath, Avindra
AU - Nelson, Robert
AU - Freedman, Mark
AU - Brunet, Donald
AU - Paulseth, John E.
AU - Rice, George
AU - O'Connor, Paul
AU - Duquette, Pierre
AU - Lapierre, Yves
AU - Francis, Gordon
AU - Bouchard, Jean Pierre
AU - Murray, T. John
AU - Bhan, Virender
AU - Maxner, Charles
AU - Pryse-Phillips, William
AU - Stefanelli, Mark
AU - Sadovnick, A. Dessa
AU - Risch, Neil
AU - Ebers, George C.
PY - 2001
Y1 - 2001
N2 - Four published genome screens have identified a number of markers with increased sharing in multiple sclerosis (MS) families, although none has reached statistical significance. One hundred and five markers previously identified as showing increased sharing in Canadian, British, Finnish, and American genome screens were genotyped in 219 sibling pairs ascertained from the database of the Canadian Collaborative Project on Genetic Susceptibility to MS (CCPGSMS). No markers examined met criteria for significant linkage. Markers located at 5p14 and 17q22 were analyzed in a total of 333 sibling pairs and attained mlod scores of 2.27 and 1.14, respectively. The known HLA Class II DRB1 association with MS was confirmed (P
AB - Four published genome screens have identified a number of markers with increased sharing in multiple sclerosis (MS) families, although none has reached statistical significance. One hundred and five markers previously identified as showing increased sharing in Canadian, British, Finnish, and American genome screens were genotyped in 219 sibling pairs ascertained from the database of the Canadian Collaborative Project on Genetic Susceptibility to MS (CCPGSMS). No markers examined met criteria for significant linkage. Markers located at 5p14 and 17q22 were analyzed in a total of 333 sibling pairs and attained mlod scores of 2.27 and 1.14, respectively. The known HLA Class II DRB1 association with MS was confirmed (P
KW - Linkage analysis
KW - Multiple sclerosis
KW - Susceptibility loci
UR - http://www.scopus.com/inward/record.url?scp=18044399829&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=18044399829&partnerID=8YFLogxK
U2 - 10.1007/s100480100113
DO - 10.1007/s100480100113
M3 - Article
C2 - 11523565
AN - SCOPUS:18044399829
VL - 3
SP - 145
EP - 151
JO - Neurogenetics
JF - Neurogenetics
SN - 1364-6745
IS - 3
ER -