Genetic susceptibility to ischemic stroke in Russians

M. G. Parfenov, B. V. Titov, M. A. Sudomoina, M. Yu Martynov, Alexander Favorov, M. F. Ochs, E. I. Gusev, O. O. Favorova

Research output: Contribution to journalArticle

Abstract

The frequencies of alleles and genotypes for ten functionally significant single-nucleotide polymorphisms were determined in the FGA, FGB, APOE, LPL, ACE, and CMA1 genes for Russian ischemic stroke (IS) patients and for a control group of Russians similar in gender and age distribution. The groups showed no significant differences in the frequencies of individual alleles or genotypes for any polymorphism studied. However, complex analysis of genetic susceptibility by the APSampler algorithm demonstrated that carriership of the APOE (-491A) allele predisposed to IS (p = 0.044, OR 3.8, 95% CI 1.0-15.1). Correspondingly, the APOE (-491T/T) genotype was associated with resistance to IS (p = 0.044, OR 0.26, 95% CI 0.07-1.0). The carriership of FGB (-249C) allele together with this genotype enhanced its protective potential, reducing the p value of the combination twofold (OR 0.17, 95% CI 0.04-0.8). Two more protective combinations were identified: biallelic APOE (-427C) + LPL (1595G) and triallelic APOE (-491C) + LPL (1595G) + CMA1 (-1903G). In both cases, p = 0.0052, OR 0.18, and 95% CI 0.05-0.66. Altogether, involvement in the formation of IS risk in Russians was evidenced for alleles of four genes: APOE, FGB, LPL, and CMA1; the APOE involvement was demonstrated for alleles of two polymorphic loci: -491T and -427C. Linkage analysis suggested that these loci were involved in IS resistance independently of each other.

Original languageEnglish (US)
Pages (from-to)873-880
Number of pages8
JournalMolecular Biology
Volume43
Issue number5
DOIs
StatePublished - Oct 2009

Fingerprint

Genetic Predisposition to Disease
Stroke
Alleles
Genotype
Gene Frequency
Age Distribution
Genes
Single Nucleotide Polymorphism
Control Groups

Keywords

  • Allelic polymorphism
  • DNA
  • Genes
  • Genotyping
  • Haplotypes
  • Human
  • Ischemic stroke
  • Polymerase chain reaction
  • Russians

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology

Cite this

Parfenov, M. G., Titov, B. V., Sudomoina, M. A., Martynov, M. Y., Favorov, A., Ochs, M. F., ... Favorova, O. O. (2009). Genetic susceptibility to ischemic stroke in Russians. Molecular Biology, 43(5), 873-880. https://doi.org/10.1134/S0026893309050185

Genetic susceptibility to ischemic stroke in Russians. / Parfenov, M. G.; Titov, B. V.; Sudomoina, M. A.; Martynov, M. Yu; Favorov, Alexander; Ochs, M. F.; Gusev, E. I.; Favorova, O. O.

In: Molecular Biology, Vol. 43, No. 5, 10.2009, p. 873-880.

Research output: Contribution to journalArticle

Parfenov, MG, Titov, BV, Sudomoina, MA, Martynov, MY, Favorov, A, Ochs, MF, Gusev, EI & Favorova, OO 2009, 'Genetic susceptibility to ischemic stroke in Russians', Molecular Biology, vol. 43, no. 5, pp. 873-880. https://doi.org/10.1134/S0026893309050185
Parfenov MG, Titov BV, Sudomoina MA, Martynov MY, Favorov A, Ochs MF et al. Genetic susceptibility to ischemic stroke in Russians. Molecular Biology. 2009 Oct;43(5):873-880. https://doi.org/10.1134/S0026893309050185
Parfenov, M. G. ; Titov, B. V. ; Sudomoina, M. A. ; Martynov, M. Yu ; Favorov, Alexander ; Ochs, M. F. ; Gusev, E. I. ; Favorova, O. O. / Genetic susceptibility to ischemic stroke in Russians. In: Molecular Biology. 2009 ; Vol. 43, No. 5. pp. 873-880.
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abstract = "The frequencies of alleles and genotypes for ten functionally significant single-nucleotide polymorphisms were determined in the FGA, FGB, APOE, LPL, ACE, and CMA1 genes for Russian ischemic stroke (IS) patients and for a control group of Russians similar in gender and age distribution. The groups showed no significant differences in the frequencies of individual alleles or genotypes for any polymorphism studied. However, complex analysis of genetic susceptibility by the APSampler algorithm demonstrated that carriership of the APOE (-491A) allele predisposed to IS (p = 0.044, OR 3.8, 95{\%} CI 1.0-15.1). Correspondingly, the APOE (-491T/T) genotype was associated with resistance to IS (p = 0.044, OR 0.26, 95{\%} CI 0.07-1.0). The carriership of FGB (-249C) allele together with this genotype enhanced its protective potential, reducing the p value of the combination twofold (OR 0.17, 95{\%} CI 0.04-0.8). Two more protective combinations were identified: biallelic APOE (-427C) + LPL (1595G) and triallelic APOE (-491C) + LPL (1595G) + CMA1 (-1903G). In both cases, p = 0.0052, OR 0.18, and 95{\%} CI 0.05-0.66. Altogether, involvement in the formation of IS risk in Russians was evidenced for alleles of four genes: APOE, FGB, LPL, and CMA1; the APOE involvement was demonstrated for alleles of two polymorphic loci: -491T and -427C. Linkage analysis suggested that these loci were involved in IS resistance independently of each other.",
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AU - Ochs, M. F.

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