Genetic susceptibility for chronic lymphocytic leukemia among Chinese in Hong Kong

Qing Lan, Wing Yan Au, Stephen Chanock, Jovic Tse, Kit fai Wong, Min Shen, L. P. Siu, Jeff Yuenger, Meredith Yeager, Howard Dean Hosgood, Mark P. Purdue, Raymond Liang, Nathaniel Rothman

Research output: Contribution to journalArticle

Abstract

The genetic basis of chronic lymphocytic leukemia (CLL) has not been fully elucidated to date. Although it is the most common haematological malignancy in Caucasians, it is uncommon among Asians. A recent genome-wide scan of CLL in Caucasians, which was carried out in the UK, identified six variants showing strong association. We attempted to replicate these findings in 71 patients with CLL and 1273 controls in Hong Kong Chinese. Three of the six variants were significantly associated with CLL. The rs872071 variant (Odds Ratio (95% Confidence Interval) = 1.78 (1.25-2.53), P = 0.0013) in the IRF4 gene region showed the strongest association, similar to that reported in the UK study. Polymorphisms in SP140 and ACOXL were also associated with risk of CLL. Further, the mean allele frequencies of the six variants were moderately (59%) to extremely (0.5%) lower in the Chinese population compared with Caucasians. These results suggest that variants in three loci may contribute to risk of CLL among Chinese.

Original languageEnglish (US)
Pages (from-to)492-495
Number of pages4
JournalEuropean Journal of Haematology
Volume85
Issue number6
DOIs
StatePublished - Dec 2010
Externally publishedYes

Fingerprint

Hong Kong
B-Cell Chronic Lymphocytic Leukemia
Genetic Predisposition to Disease
Hematologic Neoplasms
Gene Frequency
Odds Ratio
Genome
Confidence Intervals
Population
Genes

Keywords

  • Chinese
  • Chronic lymphocytic leukemia
  • Genetic polymorphism

ASJC Scopus subject areas

  • Hematology

Cite this

Lan, Q., Au, W. Y., Chanock, S., Tse, J., Wong, K. F., Shen, M., ... Rothman, N. (2010). Genetic susceptibility for chronic lymphocytic leukemia among Chinese in Hong Kong. European Journal of Haematology, 85(6), 492-495. https://doi.org/10.1111/j.1600-0609.2010.01518.x

Genetic susceptibility for chronic lymphocytic leukemia among Chinese in Hong Kong. / Lan, Qing; Au, Wing Yan; Chanock, Stephen; Tse, Jovic; Wong, Kit fai; Shen, Min; Siu, L. P.; Yuenger, Jeff; Yeager, Meredith; Hosgood, Howard Dean; Purdue, Mark P.; Liang, Raymond; Rothman, Nathaniel.

In: European Journal of Haematology, Vol. 85, No. 6, 12.2010, p. 492-495.

Research output: Contribution to journalArticle

Lan, Q, Au, WY, Chanock, S, Tse, J, Wong, KF, Shen, M, Siu, LP, Yuenger, J, Yeager, M, Hosgood, HD, Purdue, MP, Liang, R & Rothman, N 2010, 'Genetic susceptibility for chronic lymphocytic leukemia among Chinese in Hong Kong', European Journal of Haematology, vol. 85, no. 6, pp. 492-495. https://doi.org/10.1111/j.1600-0609.2010.01518.x
Lan, Qing ; Au, Wing Yan ; Chanock, Stephen ; Tse, Jovic ; Wong, Kit fai ; Shen, Min ; Siu, L. P. ; Yuenger, Jeff ; Yeager, Meredith ; Hosgood, Howard Dean ; Purdue, Mark P. ; Liang, Raymond ; Rothman, Nathaniel. / Genetic susceptibility for chronic lymphocytic leukemia among Chinese in Hong Kong. In: European Journal of Haematology. 2010 ; Vol. 85, No. 6. pp. 492-495.
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abstract = "The genetic basis of chronic lymphocytic leukemia (CLL) has not been fully elucidated to date. Although it is the most common haematological malignancy in Caucasians, it is uncommon among Asians. A recent genome-wide scan of CLL in Caucasians, which was carried out in the UK, identified six variants showing strong association. We attempted to replicate these findings in 71 patients with CLL and 1273 controls in Hong Kong Chinese. Three of the six variants were significantly associated with CLL. The rs872071 variant (Odds Ratio (95{\%} Confidence Interval) = 1.78 (1.25-2.53), P = 0.0013) in the IRF4 gene region showed the strongest association, similar to that reported in the UK study. Polymorphisms in SP140 and ACOXL were also associated with risk of CLL. Further, the mean allele frequencies of the six variants were moderately (59{\%}) to extremely (0.5{\%}) lower in the Chinese population compared with Caucasians. These results suggest that variants in three loci may contribute to risk of CLL among Chinese.",
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