Genetic strategies for elucidating insulin-like growth factor action in bone

Thomas L. Clemens, Steven D. Chernausek

Research output: Contribution to journalReview articlepeer-review

Abstract

While it is universally accepted that IGFs serve important roles in bone acquisition and maintenance, the precise cellular targets and molecular mechanisms responsible for their actions have remained poorly understood. Recent advances in genetic techniques to manipulate the mouse genome have enabled the examination of individual components of the IGF system in vivo. Observations in these mouse models have provided new insights into the skeletal actions of IGF which have significant implications for understanding IGF action in human bone.

Original languageEnglish (US)
Pages (from-to)195-199
Number of pages5
JournalGrowth Hormone and IGF Research
Volume14
Issue number3
DOIs
StatePublished - Jun 2004
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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