Genetic risk factors for longitudinal changes in structural MRI in former organolead workers

Bryan D. James, Brian S Caffo, Walter F. Stewart, David Mark Yousem, Christos Davatzikos, Brian S Schwartz

Research output: Contribution to journalArticle

Abstract

This study examined associations between polymorphisms in three genes, apolipoprotein E (APOE), angiotensin converting enzyme (ACE), and vitamin D receptor (VDR), and longitudinal change in brain volumes and white matter lesions (WML) as well as effect modification by cardiovascular factors and tibia lead concentrations. Two MRIs, an average of 5 years apart, were obtained for 317 former organolead workers and 45 population-based controls. Both regions-of-interest and voxel-wise analyses were conducted. APOE ε3/ε4 and ε4/ε4 genotypes were associated with less decline in white matter volumes. There was some evidence of interaction between genetic polymorphisms and cardiovascular risk factors (ACE and high-density lipoprotein; VDR and diabetes) on brain volume decline. The VDR FokI ff genotype was associated with an increase in WML (no association for APOE or ACE). This study expands our understanding of how genetic precursors of dementia and cardiovascular diseases are related to changes in brain structure.

Original languageEnglish (US)
Article number362189
JournalJournal of Aging Research
Volume2011
DOIs
StatePublished - 2011

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Calcitriol Receptors
Peptidyl-Dipeptidase A
Apolipoproteins E
Brain
Genotype
Apolipoprotein E3
Apolipoprotein E4
Population Control
Genetic Polymorphisms
HDL Lipoproteins
Tibia
Dementia
Cardiovascular Diseases
Genes
White Matter

ASJC Scopus subject areas

  • Geriatrics and Gerontology

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Genetic risk factors for longitudinal changes in structural MRI in former organolead workers. / James, Bryan D.; Caffo, Brian S; Stewart, Walter F.; Yousem, David Mark; Davatzikos, Christos; Schwartz, Brian S.

In: Journal of Aging Research, Vol. 2011, 362189, 2011.

Research output: Contribution to journalArticle

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