Genetic relatedness of selected clinical and environmental non-O1/O139 Vibrio cholerae

Antonina Aydanian, Li Tang, Yuansha Chen, J. Glenn Morris, Peter Olsen, Judith A. Johnson, G. Balakrish Nair, O. Colin Stine

Research output: Contribution to journalArticlepeer-review

Abstract

Background: In an attempt to better understand the non-O1/O139 isolates of Vibrio cholerae, a systematic study of clinical and environmental isolates collected from various geographical locations between the years 1932 and 1998 was conducted. Methods: Ninety-nine V. cholerae isolates collected from clinical and environmental sources from various geographical regions between 1932 and 1998 were studied by sequencing seven housekeeping genes. Genetic relatedness was defined by multiple methods that allow for the observed high levels of recombination. Results: Four V. cholerae subpopulations were determined. One subpopulation contained mostly environmental isolates, a second contained the cholera toxin-positive serogroup O1/O139 isolates, and the other two subpopulations were enriched for non-O1/O139 clinical isolates that were frequently clonally related to each other. Conclusions: The data suggest that many of these non-O1/O139 clinical isolates were phylogenetically related to common ancestors, even though the isolates had been collected up to 36 years apart and from different countries or continents.

Original languageEnglish (US)
Pages (from-to)152-158
Number of pages7
JournalInternational Journal of Infectious Diseases
Volume37
DOIs
StatePublished - 2015
Externally publishedYes

Keywords

  • Phylogenetically related
  • Recombination
  • Subpopulations
  • Vibrio cholerae

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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