TY - JOUR
T1 - Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis
AU - Rath, Poonam
AU - Huang, Chengdong
AU - Wang, Tao
AU - Wang, Tianzhi
AU - Li, Huilin
AU - Prados-Rosales, Rafael
AU - Elemento, Olivier
AU - Casadevall, Arturo
AU - Nathan, Carl F.
PY - 2013/12/3
Y1 - 2013/12/3
N2 - Mycobacterium tuberculosis (Mtb) restrains immune responses well enough to escape eradication but elicits enough immunopathology to ensure its transmission. Here we provide evidence that this host-pathogen relationship is regulated in part by a cytosolic, membrane-associated protein with a unique structural fold, encoded by the Mtb gene rv0431. The protein acts by regulating the quantity of Mtb-derived membrane vesicles bearing Toll-like receptor 2 ligands, including the lipoproteins LpqH and SodC. We propose that rv0431 be named "vesiculogenesis and immune response regulator".
AB - Mycobacterium tuberculosis (Mtb) restrains immune responses well enough to escape eradication but elicits enough immunopathology to ensure its transmission. Here we provide evidence that this host-pathogen relationship is regulated in part by a cytosolic, membrane-associated protein with a unique structural fold, encoded by the Mtb gene rv0431. The protein acts by regulating the quantity of Mtb-derived membrane vesicles bearing Toll-like receptor 2 ligands, including the lipoproteins LpqH and SodC. We propose that rv0431 be named "vesiculogenesis and immune response regulator".
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U2 - 10.1073/pnas.1320118110
DO - 10.1073/pnas.1320118110
M3 - Article
C2 - 24248369
AN - SCOPUS:84889637802
SN - 0027-8424
VL - 110
SP - E4790-E4797
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 49
ER -