Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis

Poonam Rath, Chengdong Huang, Tao Wang, Tianzhi Wang, Huilin Li, Rafael Prados-Rosales, Olivier Elemento, Arturo Casadevall, Carl F. Nathan

Research output: Contribution to journalArticlepeer-review

Abstract

Mycobacterium tuberculosis (Mtb) restrains immune responses well enough to escape eradication but elicits enough immunopathology to ensure its transmission. Here we provide evidence that this host-pathogen relationship is regulated in part by a cytosolic, membrane-associated protein with a unique structural fold, encoded by the Mtb gene rv0431. The protein acts by regulating the quantity of Mtb-derived membrane vesicles bearing Toll-like receptor 2 ligands, including the lipoproteins LpqH and SodC. We propose that rv0431 be named "vesiculogenesis and immune response regulator".

Original languageEnglish (US)
Pages (from-to)E4790-E4797
JournalProceedings of the National Academy of Sciences of the United States of America
Volume110
Issue number49
DOIs
StatePublished - Dec 3 2013
Externally publishedYes

ASJC Scopus subject areas

  • General

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