Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis

Poonam Rath, Chengdong Huang, Tao Wang, Tianzhi Wang, Huilin Li, Rafael Prados-Rosales, Olivier Elemento, Arturo Casadevall, Carl F. Nathan

Research output: Contribution to journalArticle

Abstract

Mycobacterium tuberculosis (Mtb) restrains immune responses well enough to escape eradication but elicits enough immunopathology to ensure its transmission. Here we provide evidence that this host-pathogen relationship is regulated in part by a cytosolic, membrane-associated protein with a unique structural fold, encoded by the Mtb gene rv0431. The protein acts by regulating the quantity of Mtb-derived membrane vesicles bearing Toll-like receptor 2 ligands, including the lipoproteins LpqH and SodC. We propose that rv0431 be named "vesiculogenesis and immune response regulator".

Original languageEnglish (US)
JournalProceedings of the National Academy of Sciences of the United States of America
Volume110
Issue number49
DOIs
StatePublished - Dec 3 2013
Externally publishedYes

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Immunomodulation
Mycobacterium tuberculosis
Toll-Like Receptor 2
Lipoproteins
Membrane Proteins
Ligands
Membranes
Genes
Proteins

ASJC Scopus subject areas

  • General

Cite this

Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis. / Rath, Poonam; Huang, Chengdong; Wang, Tao; Wang, Tianzhi; Li, Huilin; Prados-Rosales, Rafael; Elemento, Olivier; Casadevall, Arturo; Nathan, Carl F.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, No. 49, 03.12.2013.

Research output: Contribution to journalArticle

Rath, Poonam ; Huang, Chengdong ; Wang, Tao ; Wang, Tianzhi ; Li, Huilin ; Prados-Rosales, Rafael ; Elemento, Olivier ; Casadevall, Arturo ; Nathan, Carl F. / Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis. In: Proceedings of the National Academy of Sciences of the United States of America. 2013 ; Vol. 110, No. 49.
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