Genetic regulation of platelet receptor expression and function: Application in clinical practice and drug development

Marlene S. Williams, Ethan J. Weiss, Marc S. Sabatine, Daniel I. Simon, Wadie F. Bahou, Lewis C. Becker, Leslie V. Parise, Harold L. Dauerman, Patricia A. French, Susan S. Smyth, Richard C. Becker

Research output: Contribution to journalArticle

Abstract

Understanding genetic contributions to platelet function could have profound clinical ramifications for personalizing platelet-directed pharmacotherapy, by providing insight into the risks and possible benefits associated with specific genotypes. This article represents an integrated summary of presentations related to genetic regulation of platelet receptor expression and function given at the Fifth Annual Platelet Colloquium in January 2010. It is supplemented with additional highlights from the literature covering (1) approaches to determining and evidence for the associations of genetic variants with platelet hypo- and hyperresponsive phenotypes, (2) the ramifications of these polymorphisms with regard to clinical responses to antiplatelet therapies, and (3) the role of platelet function/genetic testing in guiding antiplatelet therapy.

Original languageEnglish (US)
Pages (from-to)2372-2384
Number of pages13
JournalArteriosclerosis, thrombosis, and vascular biology
Volume30
Issue number12
DOIs
StatePublished - Dec 2010

Keywords

  • gene expression
  • hemostasis
  • platelets
  • receptors
  • thrombosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Genetic regulation of platelet receptor expression and function: Application in clinical practice and drug development'. Together they form a unique fingerprint.

  • Cite this

    Williams, M. S., Weiss, E. J., Sabatine, M. S., Simon, D. I., Bahou, W. F., Becker, L. C., Parise, L. V., Dauerman, H. L., French, P. A., Smyth, S. S., & Becker, R. C. (2010). Genetic regulation of platelet receptor expression and function: Application in clinical practice and drug development. Arteriosclerosis, thrombosis, and vascular biology, 30(12), 2372-2384. https://doi.org/10.1161/ATVBAHA.110.218131