Genetic regulation of platelet receptor expression and function: Application in clinical practice and drug development

Marlene S. Williams; Ethan J. Weiss; Marc S. Sabatine; Daniel I. Simon; Wadie F. Bahou; Lewis C. Becker; Leslie V. Parise; Harold L. Dauerman; Patricia A. French; Susan S. Smyth; Richard C. Becker

doi:10.1161/ATVBAHA.110.218131

Genetic regulation of platelet receptor expression and function: Application in clinical practice and drug development

Marlene S. Williams, Ethan J. Weiss, Marc S. Sabatine, Daniel I. Simon, Wadie F. Bahou, Lewis C. Becker, Leslie V. Parise, Harold L. Dauerman, Patricia A. French, Susan S. Smyth, Richard C. Becker

School of Medicine

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Understanding genetic contributions to platelet function could have profound clinical ramifications for personalizing platelet-directed pharmacotherapy, by providing insight into the risks and possible benefits associated with specific genotypes. This article represents an integrated summary of presentations related to genetic regulation of platelet receptor expression and function given at the Fifth Annual Platelet Colloquium in January 2010. It is supplemented with additional highlights from the literature covering (1) approaches to determining and evidence for the associations of genetic variants with platelet hypo- and hyperresponsive phenotypes, (2) the ramifications of these polymorphisms with regard to clinical responses to antiplatelet therapies, and (3) the role of platelet function/genetic testing in guiding antiplatelet therapy.

Original language	English (US)
Pages (from-to)	2372-2384
Number of pages	13
Journal	Arteriosclerosis, thrombosis, and vascular biology
Volume	30
Issue number	12
DOIs	https://doi.org/10.1161/ATVBAHA.110.218131
State	Published - Dec 2010

Keywords

gene expression
hemostasis
platelets
receptors
thrombosis

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1161/ATVBAHA.110.218131

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Williams, M. S., Weiss, E. J., Sabatine, M. S., Simon, D. I., Bahou, W. F., Becker, L. C., Parise, L. V., Dauerman, H. L., French, P. A., Smyth, S. S., & Becker, R. C. (2010). Genetic regulation of platelet receptor expression and function: Application in clinical practice and drug development. Arteriosclerosis, thrombosis, and vascular biology, 30(12), 2372-2384. https://doi.org/10.1161/ATVBAHA.110.218131

Williams, MS, Weiss, EJ, Sabatine, MS, Simon, DI, Bahou, WF, Becker, LC, Parise, LV, Dauerman, HL, French, PA, Smyth, SS & Becker, RC 2010, 'Genetic regulation of platelet receptor expression and function: Application in clinical practice and drug development', Arteriosclerosis, thrombosis, and vascular biology, vol. 30, no. 12, pp. 2372-2384. https://doi.org/10.1161/ATVBAHA.110.218131

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AU - Becker, Lewis C.

AU - Parise, Leslie V.

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Genetic regulation of platelet receptor expression and function: Application in clinical practice and drug development

Abstract

Keywords

ASJC Scopus subject areas

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