Genetic Predisposition to Myelodysplastic Syndrome in Clinical Practice

Kristen E. Schratz, Amy E. DeZern

Research output: Contribution to journalReview articlepeer-review

Abstract

Myelodysplastic syndromes (MDSs) are a heterogeneous group of marrow failure disorders that primarily affect older persons but also occur at a lower frequency in children and young adults. There is increasing recognition of an inherited predisposition to MDS as well as other myeloid malignancies for patients of all ages. Germline predisposition to MDS can occur as part of a syndrome or sporadic disease. The timely diagnosis of an underlying genetic predisposition in the setting of MDS is important. This article delineates germline genetic causes of MDS and provides a scaffold for the diagnosis and management of patients in this context.

Original languageEnglish (US)
Pages (from-to)333-356
Number of pages24
JournalHematology/Oncology Clinics of North America
Volume34
Issue number2
DOIs
StatePublished - Apr 2020

Keywords

  • Diagnostic testing
  • Germline mutations
  • Hematopoietic stem cell transplant
  • Inherited predisposition
  • Myelodysplastic syndrome
  • Somatic mutations

ASJC Scopus subject areas

  • Hematology
  • Oncology

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