Genetic predisposition to mosaic Y chromosome loss in blood

International Lung Cancer Consortium (INTEGRAL-ILCCO), The Breast Cancer Association Consortium, Consortium of Investigators of Modifiers of BRCA1/2, The Endometrial Cancer Association Consortium, The Ovarian Cancer Association Consortium, The Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) Consortium, The Kidney Cancer GWAS Meta-Analysis Project, eQTLGen Consortium, Biobank-based Integrative Omics Study (BIOS) Consortium, 23andMe Research Team

Research output: Contribution to journalArticle

Abstract

Mosaic loss of chromosome Y (LOY) in circulating white blood cells is the most common form of clonal mosaicism1–5, yet our knowledge of the causes and consequences of this is limited. Here, using a computational approach, we estimate that 20% of the male population represented in the UK Biobank study (n = 205,011) has detectable LOY. We identify 156 autosomal genetic determinants of LOY, which we replicate in 757,114 men of European and Japanese ancestry. These loci highlight genes that are involved in cell-cycle regulation and cancer susceptibility, as well as somatic drivers of tumour growth and targets of cancer therapy. We demonstrate that genetic susceptibility to LOY is associated with non-haematological effects on health in both men and women, which supports the hypothesis that clonal haematopoiesis is a biomarker of genomic instability in other tissues. Single-cell RNA sequencing identifies dysregulated expression of autosomal genes in leukocytes with LOY and provides insights into why clonal expansion of these cells may occur. Collectively, these data highlight the value of studying clonal mosaicism to uncover fundamental mechanisms that underlie cancer and other ageing-related diseases.

Original languageEnglish (US)
Pages (from-to)652-657
Number of pages6
JournalNature
Volume575
Issue number7784
DOIs
StatePublished - Nov 28 2019

ASJC Scopus subject areas

  • General

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    International Lung Cancer Consortium (INTEGRAL-ILCCO), The Breast Cancer Association Consortium, Consortium of Investigators of Modifiers of BRCA1/2, The Endometrial Cancer Association Consortium, The Ovarian Cancer Association Consortium, The Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) Consortium, The Kidney Cancer GWAS Meta-Analysis Project, eQTLGen Consortium, Biobank-based Integrative Omics Study (BIOS) Consortium, & 23andMe Research Team (2019). Genetic predisposition to mosaic Y chromosome loss in blood. Nature, 575(7784), 652-657. https://doi.org/10.1038/s41586-019-1765-3