Genetic predictors of acute and chronic pain

Robert R. Edwards

Research output: Contribution to journalArticle

Abstract

Although broad agreement exists that genetic factors are important contributors to individual differences in pain sensitivity and risk for developing painful clinical conditions, the field of pain genetics is still in its infancy. This article reviews recent human studies of the genetics of acute and chronic pain, which implicate polymorphisms in genes coding for catechol-O-methyltransferase activity and μ-opioid receptors, among a number of others, as influential in explaining variability among the pain responses of individuals. Growing interest in pain genetics and accelerating methodologic advances in the field will almost certainly alter our understanding of which genes contribute to nociception and how dynamic interactions between multiple genes and environmental events shape the human experience of pain.

Original languageEnglish (US)
Pages (from-to)411-417
Number of pages7
JournalCurrent Rheumatology Reports
Volume8
Issue number6
DOIs
StatePublished - Dec 2006

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Acute Pain
Chronic Pain
Pain
Genes
Catechol O-Methyltransferase
Nociception
Medical Genetics
Opioid Receptors
Individuality

ASJC Scopus subject areas

  • Rheumatology

Cite this

Genetic predictors of acute and chronic pain. / Edwards, Robert R.

In: Current Rheumatology Reports, Vol. 8, No. 6, 12.2006, p. 411-417.

Research output: Contribution to journalArticle

Edwards, Robert R. / Genetic predictors of acute and chronic pain. In: Current Rheumatology Reports. 2006 ; Vol. 8, No. 6. pp. 411-417.
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