Genetic polymorphisms in the aryl hydrocarbon receptor signaling pathway as potential risk factors of menopausal hot flashes

Ayelet Ziv-Gal, Lisa Gallicchio, Susan R. Miller, Howard A Zacur, Jodi A. Flaws

Research output: Contribution to journalArticle

Abstract

Objective: We sought to determine if genetic polymorphisms in the aryl hydrocarbon receptor signaling pathway are associated with menopausal hot flashes via hormone levels. Study Design: Women (n = 639) aged 45-54 years completed a study survey and provided blood for genetic and hormone analyses. The associations were analyzed using multivariable logistic regression and generalized linear models. Results: Women carrying CYP1B1 (rs1800440) GG genotype had 3-fold greater odds of experiencing hot flashes for

Original languageEnglish (US)
JournalAmerican Journal of Obstetrics and Gynecology
Volume207
Issue number3
DOIs
StatePublished - Sep 2012

Fingerprint

Hot Flashes
Aryl Hydrocarbon Receptors
Genetic Polymorphisms
Hormones
Linear Models
Logistic Models
Genotype
Surveys and Questionnaires

Keywords

  • AHR (aryl hydrocarbon receptor)
  • CYP1B1 (cytochrome P450 1B1)
  • hot flashes
  • polymorphism
  • risk factor

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Genetic polymorphisms in the aryl hydrocarbon receptor signaling pathway as potential risk factors of menopausal hot flashes. / Ziv-Gal, Ayelet; Gallicchio, Lisa; Miller, Susan R.; Zacur, Howard A; Flaws, Jodi A.

In: American Journal of Obstetrics and Gynecology, Vol. 207, No. 3, 09.2012.

Research output: Contribution to journalArticle

@article{78518fb649124380921d48baa6800333,
title = "Genetic polymorphisms in the aryl hydrocarbon receptor signaling pathway as potential risk factors of menopausal hot flashes",
abstract = "Objective: We sought to determine if genetic polymorphisms in the aryl hydrocarbon receptor signaling pathway are associated with menopausal hot flashes via hormone levels. Study Design: Women (n = 639) aged 45-54 years completed a study survey and provided blood for genetic and hormone analyses. The associations were analyzed using multivariable logistic regression and generalized linear models. Results: Women carrying CYP1B1 (rs1800440) GG genotype had 3-fold greater odds of experiencing hot flashes for",
keywords = "AHR (aryl hydrocarbon receptor), CYP1B1 (cytochrome P450 1B1), hot flashes, polymorphism, risk factor",
author = "Ayelet Ziv-Gal and Lisa Gallicchio and Miller, {Susan R.} and Zacur, {Howard A} and Flaws, {Jodi A.}",
year = "2012",
month = "9",
doi = "10.1016/j.ajog.2012.05.019",
language = "English (US)",
volume = "207",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "3",

}

TY - JOUR

T1 - Genetic polymorphisms in the aryl hydrocarbon receptor signaling pathway as potential risk factors of menopausal hot flashes

AU - Ziv-Gal, Ayelet

AU - Gallicchio, Lisa

AU - Miller, Susan R.

AU - Zacur, Howard A

AU - Flaws, Jodi A.

PY - 2012/9

Y1 - 2012/9

N2 - Objective: We sought to determine if genetic polymorphisms in the aryl hydrocarbon receptor signaling pathway are associated with menopausal hot flashes via hormone levels. Study Design: Women (n = 639) aged 45-54 years completed a study survey and provided blood for genetic and hormone analyses. The associations were analyzed using multivariable logistic regression and generalized linear models. Results: Women carrying CYP1B1 (rs1800440) GG genotype had 3-fold greater odds of experiencing hot flashes for

AB - Objective: We sought to determine if genetic polymorphisms in the aryl hydrocarbon receptor signaling pathway are associated with menopausal hot flashes via hormone levels. Study Design: Women (n = 639) aged 45-54 years completed a study survey and provided blood for genetic and hormone analyses. The associations were analyzed using multivariable logistic regression and generalized linear models. Results: Women carrying CYP1B1 (rs1800440) GG genotype had 3-fold greater odds of experiencing hot flashes for

KW - AHR (aryl hydrocarbon receptor)

KW - CYP1B1 (cytochrome P450 1B1)

KW - hot flashes

KW - polymorphism

KW - risk factor

UR - http://www.scopus.com/inward/record.url?scp=84865766901&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865766901&partnerID=8YFLogxK

U2 - 10.1016/j.ajog.2012.05.019

DO - 10.1016/j.ajog.2012.05.019

M3 - Article

C2 - 22840970

AN - SCOPUS:84865766901

VL - 207

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 3

ER -