Genetic polymorphisms in IL10RA and TNF modify the association between blood transfusion and risk of non-Hodgkin lymphoma

Xiaofeng Bi; Tongzhang Zheng; Qing Lan; Zhijian Xu; Yingtai Chen; Gongjian Zhu; Francine Foss; Christopher Kim; Min Dai; Ping Zhao; Theodore Holford; Brian Leaderer; Peter Boyle; Qian Deng; Stephen J. Chanock; Nathaniel Rothman; Yawei Zhang

doi:10.1002/ajh.23244

Genetic polymorphisms in IL10RA and TNF modify the association between blood transfusion and risk of non-Hodgkin lymphoma

Xiaofeng Bi, Tongzhang Zheng, Qing Lan, Zhijian Xu, Yingtai Chen, Gongjian Zhu, Francine Foss, Christopher Kim, Min Dai, Ping Zhao, Theodore Holford, Brian Leaderer, Peter Boyle, Qian Deng, Stephen J. Chanock, Nathaniel Rothman, Yawei Zhang

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Abstract

We conducted a population-based case-control study in Connecticut women to test the hypothesis that genetic variations in Th1 and Th2 cytokine genes may modify the association between blood transfusion and risk of non-Hodgkin lymphoma (NHL). Compared with women without blood transfusion, women with a history of transfusion had an increased risk of NHL if they carried IL10RA (rs9610) GG genotype [odds ratio (OR) = 1.9, 95% confidence interval (CI): 1.1-3.2] or TNF (rs1800629) AG/AA genotypes (OR = 1.6, 95% CI: 0.9-2.7). We also found women with a history of transfusion had a decreased risk of NHL if they carried IL10RA (rs9610) AG/AA genotypes (OR = 0.6, 95% CI: 0.4-0.9) or TNF (rs1800629) GG genotype (OR = 0.7, 95% CI: 0.5-1.0). A similar pattern was also observed for B-cell lymphoma but not for T-cell lymphoma. Statistically significant interactions with blood transfusion were observed for IL10RA (rs9610) (P _{forinteraction} = 0.003) and TNF (rs1800629) (P _{forinteraction} = 0.012) for NHL overall and IL10RA (rs9610) (P _{forinteraction} = 0.001) and TNF (rs1800629) (P _{forinteraction} = 0.019) for B-cell lymphoma. The results suggest that genetic polymorphisms in TNF and IL10RA genes may modify the association between blood transfusion and NHL risk.

Original language	English (US)
Pages (from-to)	766-769
Number of pages	4
Journal	American journal of hematology
Volume	87
Issue number	8
DOIs	https://doi.org/10.1002/ajh.23244
State	Published - Aug 2012
Externally published	Yes

ASJC Scopus subject areas

Hematology

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Bi, X., Zheng, T., Lan, Q., Xu, Z., Chen, Y., Zhu, G., Foss, F., Kim, C., Dai, M., Zhao, P., Holford, T., Leaderer, B., Boyle, P., Deng, Q., Chanock, S. J., Rothman, N., & Zhang, Y. (2012). Genetic polymorphisms in IL10RA and TNF modify the association between blood transfusion and risk of non-Hodgkin lymphoma. American journal of hematology, 87(8), 766-769. https://doi.org/10.1002/ajh.23244

Bi, X, Zheng, T, Lan, Q, Xu, Z, Chen, Y, Zhu, G, Foss, F, Kim, C, Dai, M, Zhao, P, Holford, T, Leaderer, B, Boyle, P, Deng, Q, Chanock, SJ, Rothman, N & Zhang, Y 2012, 'Genetic polymorphisms in IL10RA and TNF modify the association between blood transfusion and risk of non-Hodgkin lymphoma', American journal of hematology, vol. 87, no. 8, pp. 766-769. https://doi.org/10.1002/ajh.23244

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title = "Genetic polymorphisms in IL10RA and TNF modify the association between blood transfusion and risk of non-Hodgkin lymphoma",

abstract = "We conducted a population-based case-control study in Connecticut women to test the hypothesis that genetic variations in Th1 and Th2 cytokine genes may modify the association between blood transfusion and risk of non-Hodgkin lymphoma (NHL). Compared with women without blood transfusion, women with a history of transfusion had an increased risk of NHL if they carried IL10RA (rs9610) GG genotype [odds ratio (OR) = 1.9, 95% confidence interval (CI): 1.1-3.2] or TNF (rs1800629) AG/AA genotypes (OR = 1.6, 95% CI: 0.9-2.7). We also found women with a history of transfusion had a decreased risk of NHL if they carried IL10RA (rs9610) AG/AA genotypes (OR = 0.6, 95% CI: 0.4-0.9) or TNF (rs1800629) GG genotype (OR = 0.7, 95% CI: 0.5-1.0). A similar pattern was also observed for B-cell lymphoma but not for T-cell lymphoma. Statistically significant interactions with blood transfusion were observed for IL10RA (rs9610) (P forinteraction = 0.003) and TNF (rs1800629) (P forinteraction = 0.012) for NHL overall and IL10RA (rs9610) (P forinteraction = 0.001) and TNF (rs1800629) (P forinteraction = 0.019) for B-cell lymphoma. The results suggest that genetic polymorphisms in TNF and IL10RA genes may modify the association between blood transfusion and NHL risk.",

author = "Xiaofeng Bi and Tongzhang Zheng and Qing Lan and Zhijian Xu and Yingtai Chen and Gongjian Zhu and Francine Foss and Christopher Kim and Min Dai and Ping Zhao and Theodore Holford and Brian Leaderer and Peter Boyle and Qian Deng and Chanock, {Stephen J.} and Nathaniel Rothman and Yawei Zhang",

year = "2012",

month = aug,

doi = "10.1002/ajh.23244",

language = "English (US)",

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pages = "766--769",

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T1 - Genetic polymorphisms in IL10RA and TNF modify the association between blood transfusion and risk of non-Hodgkin lymphoma

AU - Bi, Xiaofeng

AU - Zheng, Tongzhang

AU - Lan, Qing

AU - Xu, Zhijian

AU - Chen, Yingtai

AU - Zhu, Gongjian

AU - Foss, Francine

AU - Kim, Christopher

AU - Dai, Min

AU - Zhao, Ping

AU - Holford, Theodore

AU - Leaderer, Brian

AU - Boyle, Peter

AU - Deng, Qian

AU - Chanock, Stephen J.

AU - Rothman, Nathaniel

AU - Zhang, Yawei

PY - 2012/8

Y1 - 2012/8

N2 - We conducted a population-based case-control study in Connecticut women to test the hypothesis that genetic variations in Th1 and Th2 cytokine genes may modify the association between blood transfusion and risk of non-Hodgkin lymphoma (NHL). Compared with women without blood transfusion, women with a history of transfusion had an increased risk of NHL if they carried IL10RA (rs9610) GG genotype [odds ratio (OR) = 1.9, 95% confidence interval (CI): 1.1-3.2] or TNF (rs1800629) AG/AA genotypes (OR = 1.6, 95% CI: 0.9-2.7). We also found women with a history of transfusion had a decreased risk of NHL if they carried IL10RA (rs9610) AG/AA genotypes (OR = 0.6, 95% CI: 0.4-0.9) or TNF (rs1800629) GG genotype (OR = 0.7, 95% CI: 0.5-1.0). A similar pattern was also observed for B-cell lymphoma but not for T-cell lymphoma. Statistically significant interactions with blood transfusion were observed for IL10RA (rs9610) (P forinteraction = 0.003) and TNF (rs1800629) (P forinteraction = 0.012) for NHL overall and IL10RA (rs9610) (P forinteraction = 0.001) and TNF (rs1800629) (P forinteraction = 0.019) for B-cell lymphoma. The results suggest that genetic polymorphisms in TNF and IL10RA genes may modify the association between blood transfusion and NHL risk.

AB - We conducted a population-based case-control study in Connecticut women to test the hypothesis that genetic variations in Th1 and Th2 cytokine genes may modify the association between blood transfusion and risk of non-Hodgkin lymphoma (NHL). Compared with women without blood transfusion, women with a history of transfusion had an increased risk of NHL if they carried IL10RA (rs9610) GG genotype [odds ratio (OR) = 1.9, 95% confidence interval (CI): 1.1-3.2] or TNF (rs1800629) AG/AA genotypes (OR = 1.6, 95% CI: 0.9-2.7). We also found women with a history of transfusion had a decreased risk of NHL if they carried IL10RA (rs9610) AG/AA genotypes (OR = 0.6, 95% CI: 0.4-0.9) or TNF (rs1800629) GG genotype (OR = 0.7, 95% CI: 0.5-1.0). A similar pattern was also observed for B-cell lymphoma but not for T-cell lymphoma. Statistically significant interactions with blood transfusion were observed for IL10RA (rs9610) (P forinteraction = 0.003) and TNF (rs1800629) (P forinteraction = 0.012) for NHL overall and IL10RA (rs9610) (P forinteraction = 0.001) and TNF (rs1800629) (P forinteraction = 0.019) for B-cell lymphoma. The results suggest that genetic polymorphisms in TNF and IL10RA genes may modify the association between blood transfusion and NHL risk.

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U2 - 10.1002/ajh.23244

DO - 10.1002/ajh.23244

M3 - Article

C2 - 22649007

AN - SCOPUS:84863995395

SN - 0361-8609

VL - 87

SP - 766

EP - 769

JO - American journal of hematology

JF - American journal of hematology

IS - 8

ER -

Genetic polymorphisms in IL10RA and TNF modify the association between blood transfusion and risk of non-Hodgkin lymphoma

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