TY - JOUR
T1 - Genetic polymorphism in IL28B is associated with spontaneous clearance of hepatitis c virus genotype 4 infection in an egyptian cohort
AU - Kurbanov, Fuat
AU - Abdel-Hamid, Mohamed
AU - Latanich, Rachel
AU - Astemborski, Jacquie
AU - Mohamed, Mostafa
AU - Mikhail, Nabiel Mh
AU - El-Daly, Mai
AU - El-Kafrawy, Sherif
AU - Thomas, David L.
AU - Thio, Chloe L.
N1 - Funding Information:
Funding. This work was supported in part by the Egyptian Ministry of Health United States Agency for International Development (USAID)– funded Schistosomiasis Research Project (263-014.2, grant 02-04-22); and the National Institutes of Health (R01-Da13324). Potential conflicts of interest. All authors: No reported conflicts.
PY - 2011/11/1
Y1 - 2011/11/1
N2 - Single-nucleotide polymorphisms (SNPs) around IL28B are associated with spontaneous hepatitis C virus (HCV) clearance of genotypes 1 and 3 in white and African-American populations. This study investigated whether the IL28B SNP (rs12979860) is associated with spontaneous clearance of HCV, principally genotype 4, in 162 Egyptians (80 with clearance). The protective C allele was more common in those with spontaneous clearance (76.3% vs 57.9%; P =. 0006). Individuals with clearance were 3.4 (95% confidence interval, 1.8-6.5) times more likely to have C/C genotype. Thus, IL28B plays a role in spontaneous clearance of HCV genotype 4 in North Africa.
AB - Single-nucleotide polymorphisms (SNPs) around IL28B are associated with spontaneous hepatitis C virus (HCV) clearance of genotypes 1 and 3 in white and African-American populations. This study investigated whether the IL28B SNP (rs12979860) is associated with spontaneous clearance of HCV, principally genotype 4, in 162 Egyptians (80 with clearance). The protective C allele was more common in those with spontaneous clearance (76.3% vs 57.9%; P =. 0006). Individuals with clearance were 3.4 (95% confidence interval, 1.8-6.5) times more likely to have C/C genotype. Thus, IL28B plays a role in spontaneous clearance of HCV genotype 4 in North Africa.
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U2 - 10.1093/infdis/jir536
DO - 10.1093/infdis/jir536
M3 - Article
C2 - 21933876
AN - SCOPUS:80053419262
SN - 0022-1899
VL - 204
SP - 1391
EP - 1394
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 9
ER -