Genetic polymorphism in hOGG1 and susceptibility to esophageal cancer in Chinese

Deyin Xing, W. Tan, N. Song, D. Lin

Research output: Contribution to journalArticle

Abstract

Objective: To examine the association between Ser326Cys polymorphism in hOGG1 gene, which is involved in the repair of 8-hydroxyguanine in damaged DNA, and investigate the risk of squamous cell carcinoma of the esophagus in Chinese. Methods: Ser326Cys polymorphism in hOGG1 gene was determined by PCR-SSCP approach among 201 normal controls and 196 patients with squamous cell carcinoma of the esophagus. The association between this genetic polymorphism and the risk of the cancer was examined by a multivariate analysis. Results: The Cys/Cys genotype of hOGG1 was found in 21.4% of patients with the cancer and in 13.4% of controls (P<0.05). Homozygosity for the Cys/Cys genotype significantly increased the risk of developing esophageal cancer, with the odds ratio adjusted for age, sex and smoking being 1.9 (95% CI 1.3-2.6). Smoking also significantly increased esophageal cancer risk in this case-control study (adjusted OR 2.6; 95% CI 1.7- 3.9). No interaction between smoking and Cys/ Cys genotype was observed for the risk of esophageal cancer. Conclusion: Polymorphism of hOGG1 Ser326Cys may play a role in esophageal carcinogenesis.

Original languageEnglish (US)
Pages (from-to)377-380
Number of pages4
JournalChinese Journal of Medical Genetics
Volume17
Issue number6
StatePublished - 2000
Externally publishedYes

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Genetic Polymorphisms
Esophageal Neoplasms
Smoking
Genotype
Esophagus
Squamous Cell Carcinoma
Single-Stranded Conformational Polymorphism
Genes
Case-Control Studies
Neoplasms
Carcinogenesis
Multivariate Analysis
Odds Ratio
Polymerase Chain Reaction
DNA

Keywords

  • Esophageal cancer
  • Genetic polymorphism
  • hOGG1 gene
  • Susceptibility

ASJC Scopus subject areas

  • Medicine(all)
  • Genetics(clinical)

Cite this

Genetic polymorphism in hOGG1 and susceptibility to esophageal cancer in Chinese. / Xing, Deyin; Tan, W.; Song, N.; Lin, D.

In: Chinese Journal of Medical Genetics, Vol. 17, No. 6, 2000, p. 377-380.

Research output: Contribution to journalArticle

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abstract = "Objective: To examine the association between Ser326Cys polymorphism in hOGG1 gene, which is involved in the repair of 8-hydroxyguanine in damaged DNA, and investigate the risk of squamous cell carcinoma of the esophagus in Chinese. Methods: Ser326Cys polymorphism in hOGG1 gene was determined by PCR-SSCP approach among 201 normal controls and 196 patients with squamous cell carcinoma of the esophagus. The association between this genetic polymorphism and the risk of the cancer was examined by a multivariate analysis. Results: The Cys/Cys genotype of hOGG1 was found in 21.4{\%} of patients with the cancer and in 13.4{\%} of controls (P<0.05). Homozygosity for the Cys/Cys genotype significantly increased the risk of developing esophageal cancer, with the odds ratio adjusted for age, sex and smoking being 1.9 (95{\%} CI 1.3-2.6). Smoking also significantly increased esophageal cancer risk in this case-control study (adjusted OR 2.6; 95{\%} CI 1.7- 3.9). No interaction between smoking and Cys/ Cys genotype was observed for the risk of esophageal cancer. Conclusion: Polymorphism of hOGG1 Ser326Cys may play a role in esophageal carcinogenesis.",
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T1 - Genetic polymorphism in hOGG1 and susceptibility to esophageal cancer in Chinese

AU - Xing, Deyin

AU - Tan, W.

AU - Song, N.

AU - Lin, D.

PY - 2000

Y1 - 2000

N2 - Objective: To examine the association between Ser326Cys polymorphism in hOGG1 gene, which is involved in the repair of 8-hydroxyguanine in damaged DNA, and investigate the risk of squamous cell carcinoma of the esophagus in Chinese. Methods: Ser326Cys polymorphism in hOGG1 gene was determined by PCR-SSCP approach among 201 normal controls and 196 patients with squamous cell carcinoma of the esophagus. The association between this genetic polymorphism and the risk of the cancer was examined by a multivariate analysis. Results: The Cys/Cys genotype of hOGG1 was found in 21.4% of patients with the cancer and in 13.4% of controls (P<0.05). Homozygosity for the Cys/Cys genotype significantly increased the risk of developing esophageal cancer, with the odds ratio adjusted for age, sex and smoking being 1.9 (95% CI 1.3-2.6). Smoking also significantly increased esophageal cancer risk in this case-control study (adjusted OR 2.6; 95% CI 1.7- 3.9). No interaction between smoking and Cys/ Cys genotype was observed for the risk of esophageal cancer. Conclusion: Polymorphism of hOGG1 Ser326Cys may play a role in esophageal carcinogenesis.

AB - Objective: To examine the association between Ser326Cys polymorphism in hOGG1 gene, which is involved in the repair of 8-hydroxyguanine in damaged DNA, and investigate the risk of squamous cell carcinoma of the esophagus in Chinese. Methods: Ser326Cys polymorphism in hOGG1 gene was determined by PCR-SSCP approach among 201 normal controls and 196 patients with squamous cell carcinoma of the esophagus. The association between this genetic polymorphism and the risk of the cancer was examined by a multivariate analysis. Results: The Cys/Cys genotype of hOGG1 was found in 21.4% of patients with the cancer and in 13.4% of controls (P<0.05). Homozygosity for the Cys/Cys genotype significantly increased the risk of developing esophageal cancer, with the odds ratio adjusted for age, sex and smoking being 1.9 (95% CI 1.3-2.6). Smoking also significantly increased esophageal cancer risk in this case-control study (adjusted OR 2.6; 95% CI 1.7- 3.9). No interaction between smoking and Cys/ Cys genotype was observed for the risk of esophageal cancer. Conclusion: Polymorphism of hOGG1 Ser326Cys may play a role in esophageal carcinogenesis.

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KW - Susceptibility

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