Genetic pathways in pancreatic tumorigenesis

E. Gallmeier, Scott E Kern

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Tumorigenesis is a multistep process. The accumulation of newly acquired capabilities promotes cell autonomy, eventually transforming normal cells into malignant cells [1]. The predominant mechanism may be the accumulation of genetic alterations, providing certain selective advantages, in a select subset of genes [2]. Our understanding of the development of pancreatic cancer is hence based upon the identification and characterization of the genes that are mutated in this tumor type. Although the term "pancreatic cancer" comprises several histopathologically distinguishable tumor entities, including acinar cell carcinomas, pancreatoblastomas, solid-pseudopapillary tumors, mucinous cystic tumors, and intraductal papillary mucinous neoplasms, it commonly refers to pancreatic ductal adenocarcinomas, which represent the most common form of pancreatic neoplasms [3]. We focus here on a comprehensive summary of the genetic alterations identified in pancreatic ductal adenocarcinomas and their functional implications for pancreatic cancer tumorigenesis.

Original languageEnglish (US)
Title of host publicationDiseases of the Pancreas: Current Surgical Therapy
PublisherSpringer Berlin Heidelberg
Pages513-526
Number of pages14
ISBN (Print)9783540286554
DOIs
StatePublished - 2008

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Carcinogenesis
Pancreatic Neoplasms
Neoplasms
Adenocarcinoma
Acinar Cell Carcinoma
Genes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gallmeier, E., & Kern, S. E. (2008). Genetic pathways in pancreatic tumorigenesis. In Diseases of the Pancreas: Current Surgical Therapy (pp. 513-526). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-540-28656-1_52

Genetic pathways in pancreatic tumorigenesis. / Gallmeier, E.; Kern, Scott E.

Diseases of the Pancreas: Current Surgical Therapy. Springer Berlin Heidelberg, 2008. p. 513-526.

Research output: Chapter in Book/Report/Conference proceedingChapter

Gallmeier, E & Kern, SE 2008, Genetic pathways in pancreatic tumorigenesis. in Diseases of the Pancreas: Current Surgical Therapy. Springer Berlin Heidelberg, pp. 513-526. https://doi.org/10.1007/978-3-540-28656-1_52
Gallmeier E, Kern SE. Genetic pathways in pancreatic tumorigenesis. In Diseases of the Pancreas: Current Surgical Therapy. Springer Berlin Heidelberg. 2008. p. 513-526 https://doi.org/10.1007/978-3-540-28656-1_52
Gallmeier, E. ; Kern, Scott E. / Genetic pathways in pancreatic tumorigenesis. Diseases of the Pancreas: Current Surgical Therapy. Springer Berlin Heidelberg, 2008. pp. 513-526
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