Genetic Mouse Models of Schizophrenia: From Hypothesis-Based To Susceptibility Gene-Based Models

Jingshan Chen, Barbara K. Lipska, Daniel R. Weinberger

Research output: Contribution to journalReview article

Abstract

Translation of human genetic mutations into genetic mouse models is an important strategy to study the pathogenesis of schizophrenia, identify potential drug targets, and test new drugs for new antipsychotic treatments. Although it is impossible to recapitulate the full spectrum of schizophrenia symptoms in animal models, hypothesis-driven genetic mouse models have been successful in reproducing several schizophrenia-like behaviors and uncovering the roles of specific genes in dopamine and glutamine neurotransmission systems in mediating schizophrenia-like behaviors. Recent discoveries of susceptibility genes for schizophrenia and recognition of cognitive dysfunction as a core feature of schizophrenia and a phenotype of susceptibility for schizophrenia offer opportunities to develop newer genetic mouse models based on susceptibility. This new generation of genetic mouse models could shed light on the etiology of schizophrenia and lead us to new hypotheses, novel diagnostic tools, and more effective therapy.

Original languageEnglish (US)
Pages (from-to)1180-1188
Number of pages9
JournalBiological psychiatry
Volume59
Issue number12
DOIs
StatePublished - Jun 15 2006
Externally publishedYes

Keywords

  • Schizophrenia
  • animal
  • behavior
  • cognition
  • genetic
  • model

ASJC Scopus subject areas

  • Biological Psychiatry

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