Genetic markers of IgG influence the outcome of infection with hepatitis C virus

Janardan P. Pandey, Aryan M. Namboodiri, Yuqun Luo, Yuping Wu, Robert C. Elston, David L. Thomas, Hugo R. Rosen, James J. Goedert

Research output: Contribution to journalArticle

Abstract

We examined the role that immunoglobulin GM and KM allotypes - genetic markers of γ and κ chains, respectively - play in the outcome of hepatitis C virus (HCV) infection in white Americans. A total of 119 persons who had cleared HCV and 111 with persistent HCV infection were genotyped for the presence of several GM and KM determinants. Persistent HCV infection was more than three times as likely (odds ratio, 3.50; P = .01) in subjects who were carriers of the GM3 allele than in those who were noncarriers. These results show that particular GM alleles may be important determinants of the outcome of HCV infection.

Original languageEnglish (US)
Pages (from-to)1334-1336
Number of pages3
JournalJournal of Infectious Diseases
Volume198
Issue number9
DOIs
StatePublished - Nov 1 2008

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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  • Cite this

    Pandey, J. P., Namboodiri, A. M., Luo, Y., Wu, Y., Elston, R. C., Thomas, D. L., Rosen, H. R., & Goedert, J. J. (2008). Genetic markers of IgG influence the outcome of infection with hepatitis C virus. Journal of Infectious Diseases, 198(9), 1334-1336. https://doi.org/10.1086/592282