Genetic mapping of the Mx influenza virus resistance gene within the region of mouse chromosome 16 that is homologous to human chromosome 21

Roger H Reeves, B. F. O'Hara, W. J. Pavan, J. D. Gearhart, O. Haller

Research output: Contribution to journalArticle

Abstract

A total of 318 progeny from four backcrosses involving different laboratory strains and subspecies of Mus musculus were analyzed to map the Mx gene to the region of mouse chromosome 16 (MMU 16) which is homologous to human chromosome 21 (HSA 21). This result suggests that Mx will be found in the region of HSA 21 which has been implicated in Down syndrome when inherited in three copies.

Original languageEnglish (US)
Pages (from-to)4372-4375
Number of pages4
JournalJournal of Virology
Volume62
Issue number11
StatePublished - 1988

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Chromosomes, Human, Pair 16
Chromosomes, Human, Pair 21
Human Chromosomes
Orthomyxoviridae
chromosome mapping
chromosomes
Down syndrome
mice
Mus musculus
Down Syndrome
Genes
genes

ASJC Scopus subject areas

  • Immunology

Cite this

Genetic mapping of the Mx influenza virus resistance gene within the region of mouse chromosome 16 that is homologous to human chromosome 21. / Reeves, Roger H; O'Hara, B. F.; Pavan, W. J.; Gearhart, J. D.; Haller, O.

In: Journal of Virology, Vol. 62, No. 11, 1988, p. 4372-4375.

Research output: Contribution to journalArticle

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