Genetic mapping of endogenous RD-114 retroviral sequences of domestic cats

Roger H Reeves, W. G. Nash, S. J. O'Brien

Research output: Contribution to journalArticle

Abstract

The RD-114 family of endogenous retroviral sequences in domestic cats has been shown to consist of approximately 20 copies of genetically divergent virogenes per haploid genome. The chromosomal localization for four endogenous sequences (RDV1-4) was accomplished by correlating the occurrence of specific feline chromosomes with diagnostic viral DNA fragments in a panel of cat x rodent somatic cell hybrids. Analysis of the hybrid panel revealed that endogenous RD-114 sequences are dispersed on multiple cat chromosomes, that certain proviral segments are polymorphic with respect to the presence or absence of virus, and that a restriction fragment characteristic of inducible RD-114 resides on a single feline chromosome (B3), probably at a single locus.

Original languageEnglish (US)
Pages (from-to)303-306
Number of pages4
JournalJournal of Virology
Volume56
Issue number1
StatePublished - 1985
Externally publishedYes

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chromosome mapping
Cats
Chromosomes
Felidae
cats
chromosomes
Hybrid Cells
Haploidy
Viral DNA
Rodentia
Genome
Viruses
somatic cells
haploidy
rodents
viruses
loci
genome
DNA

ASJC Scopus subject areas

  • Immunology

Cite this

Genetic mapping of endogenous RD-114 retroviral sequences of domestic cats. / Reeves, Roger H; Nash, W. G.; O'Brien, S. J.

In: Journal of Virology, Vol. 56, No. 1, 1985, p. 303-306.

Research output: Contribution to journalArticle

Reeves, Roger H ; Nash, W. G. ; O'Brien, S. J. / Genetic mapping of endogenous RD-114 retroviral sequences of domestic cats. In: Journal of Virology. 1985 ; Vol. 56, No. 1. pp. 303-306.
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