Genetic mapping of a locus predisposing to human colorectal cancer

Päivi Peltomäki, Lauri A. Aaltonen, Pertti Sistonen, Lea Pylkkänen, Jukka Pekka Mecklin, Heikki Järvinen, Jane S. Green, Jeremy R. Jass, James L. Weber, Fredrick S. Leach, Gloria M. Petersen, Stanley R. Hamilton, Albert De La Chapelle, Bert Vogelstein

Research output: Contribution to journalArticle

Abstract

Genetic linkage analysis was used to determine whether a specific chromosomal locus could be implicated in families with a history of early onset cancer but with no other unique features. Close linkage of disease to anonymous microsatellite markers on chromosome 2 was demonstrated in two large kindreds. The pairwise lod scores for linkage to marker D2S123 in these kindreds were 6.39 and 1.45 at zero recombination, and multipoint linkage with flanking markers resulted in lod scores of 6.47 and 6.01. These results prove the existence of a genetically determined predisposition to colorectal cancer that has important ramifications for understanding and preventing this disease.

Original languageEnglish (US)
Pages (from-to)810-812
Number of pages3
JournalScience
Volume260
Issue number5109
StatePublished - 1993

Fingerprint

Lod Score
Colorectal Neoplasms
Genetic Linkage
Chromosomes, Human, Pair 2
Microsatellite Repeats
Genetic Recombination
Neoplasms

ASJC Scopus subject areas

  • General

Cite this

Peltomäki, P., Aaltonen, L. A., Sistonen, P., Pylkkänen, L., Mecklin, J. P., Järvinen, H., ... Vogelstein, B. (1993). Genetic mapping of a locus predisposing to human colorectal cancer. Science, 260(5109), 810-812.

Genetic mapping of a locus predisposing to human colorectal cancer. / Peltomäki, Päivi; Aaltonen, Lauri A.; Sistonen, Pertti; Pylkkänen, Lea; Mecklin, Jukka Pekka; Järvinen, Heikki; Green, Jane S.; Jass, Jeremy R.; Weber, James L.; Leach, Fredrick S.; Petersen, Gloria M.; Hamilton, Stanley R.; De La Chapelle, Albert; Vogelstein, Bert.

In: Science, Vol. 260, No. 5109, 1993, p. 810-812.

Research output: Contribution to journalArticle

Peltomäki, P, Aaltonen, LA, Sistonen, P, Pylkkänen, L, Mecklin, JP, Järvinen, H, Green, JS, Jass, JR, Weber, JL, Leach, FS, Petersen, GM, Hamilton, SR, De La Chapelle, A & Vogelstein, B 1993, 'Genetic mapping of a locus predisposing to human colorectal cancer', Science, vol. 260, no. 5109, pp. 810-812.
Peltomäki P, Aaltonen LA, Sistonen P, Pylkkänen L, Mecklin JP, Järvinen H et al. Genetic mapping of a locus predisposing to human colorectal cancer. Science. 1993;260(5109):810-812.
Peltomäki, Päivi ; Aaltonen, Lauri A. ; Sistonen, Pertti ; Pylkkänen, Lea ; Mecklin, Jukka Pekka ; Järvinen, Heikki ; Green, Jane S. ; Jass, Jeremy R. ; Weber, James L. ; Leach, Fredrick S. ; Petersen, Gloria M. ; Hamilton, Stanley R. ; De La Chapelle, Albert ; Vogelstein, Bert. / Genetic mapping of a locus predisposing to human colorectal cancer. In: Science. 1993 ; Vol. 260, No. 5109. pp. 810-812.
@article{c3764c1366e7405484c1a6b9b02db470,
title = "Genetic mapping of a locus predisposing to human colorectal cancer",
abstract = "Genetic linkage analysis was used to determine whether a specific chromosomal locus could be implicated in families with a history of early onset cancer but with no other unique features. Close linkage of disease to anonymous microsatellite markers on chromosome 2 was demonstrated in two large kindreds. The pairwise lod scores for linkage to marker D2S123 in these kindreds were 6.39 and 1.45 at zero recombination, and multipoint linkage with flanking markers resulted in lod scores of 6.47 and 6.01. These results prove the existence of a genetically determined predisposition to colorectal cancer that has important ramifications for understanding and preventing this disease.",
author = "P{\"a}ivi Peltom{\"a}ki and Aaltonen, {Lauri A.} and Pertti Sistonen and Lea Pylkk{\"a}nen and Mecklin, {Jukka Pekka} and Heikki J{\"a}rvinen and Green, {Jane S.} and Jass, {Jeremy R.} and Weber, {James L.} and Leach, {Fredrick S.} and Petersen, {Gloria M.} and Hamilton, {Stanley R.} and {De La Chapelle}, Albert and Bert Vogelstein",
year = "1993",
language = "English (US)",
volume = "260",
pages = "810--812",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "5109",

}

TY - JOUR

T1 - Genetic mapping of a locus predisposing to human colorectal cancer

AU - Peltomäki, Päivi

AU - Aaltonen, Lauri A.

AU - Sistonen, Pertti

AU - Pylkkänen, Lea

AU - Mecklin, Jukka Pekka

AU - Järvinen, Heikki

AU - Green, Jane S.

AU - Jass, Jeremy R.

AU - Weber, James L.

AU - Leach, Fredrick S.

AU - Petersen, Gloria M.

AU - Hamilton, Stanley R.

AU - De La Chapelle, Albert

AU - Vogelstein, Bert

PY - 1993

Y1 - 1993

N2 - Genetic linkage analysis was used to determine whether a specific chromosomal locus could be implicated in families with a history of early onset cancer but with no other unique features. Close linkage of disease to anonymous microsatellite markers on chromosome 2 was demonstrated in two large kindreds. The pairwise lod scores for linkage to marker D2S123 in these kindreds were 6.39 and 1.45 at zero recombination, and multipoint linkage with flanking markers resulted in lod scores of 6.47 and 6.01. These results prove the existence of a genetically determined predisposition to colorectal cancer that has important ramifications for understanding and preventing this disease.

AB - Genetic linkage analysis was used to determine whether a specific chromosomal locus could be implicated in families with a history of early onset cancer but with no other unique features. Close linkage of disease to anonymous microsatellite markers on chromosome 2 was demonstrated in two large kindreds. The pairwise lod scores for linkage to marker D2S123 in these kindreds were 6.39 and 1.45 at zero recombination, and multipoint linkage with flanking markers resulted in lod scores of 6.47 and 6.01. These results prove the existence of a genetically determined predisposition to colorectal cancer that has important ramifications for understanding and preventing this disease.

UR - http://www.scopus.com/inward/record.url?scp=0027263363&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027263363&partnerID=8YFLogxK

M3 - Article

C2 - 8484120

AN - SCOPUS:0027263363

VL - 260

SP - 810

EP - 812

JO - Science

JF - Science

SN - 0036-8075

IS - 5109

ER -