Abstract
Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10 10 to 10 15). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 × 10 5 and P = 3.6 × 10 4, respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.
Original language | English (US) |
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Pages (from-to) | 373-375 |
Number of pages | 3 |
Journal | Nature Genetics |
Volume | 42 |
Issue number | 5 |
DOIs | |
State | Published - May 2010 |
Externally published | Yes |
ASJC Scopus subject areas
- Genetics