Genetic loci influencing kidney function and chronic kidney disease

John C. Chambers, Weihua Zhang, Graham M. Lord, Pim Van Der Harst, Debbie A. Lawlor, Joban S. Sehmi, Daniel P. Gale, Mark N. Wass, Kourosh R. Ahmadi, Stephan J L Bakker, Jacqui Beckmann, Henk J G Bilo, Murielle Bochud, Morris J. Brown, Mark J. Caulfield, John M C Connell, H. Terence Cook, Ioana Cotlarciuc, George Davey Smith, Ranil De SilvaGuohong Deng, Olivier Devuyst, Lambert D. Dikkeschei, Nada Dimkovic, Mark Dockrell, Anna Dominiczak, Shah Ebrahim, Thomas Eggermann, Martin Farrall, Luigi Ferrucci, Jurgen Floege, Nita G. Forouhi, Ron T. Gansevoort, Xijin Han, Bo Hedblad, Jaap J Homan Van Der Heide, Bouke G. Hepkema, Maria Hernandez-Fuentes, Elina Hypponen, Toby Johnson, Paul E. De Jong, Nanne Kleefstra, Vasiliki Lagou, Marta Lapsley, Yun Li, Ruth J F Loos, Jian'An Luan, Karin Luttropp, Céline Maréchal, Olle Melander, Patricia B. Munroe, Louise Nordfors, Afshin Parsa, Leena Peltonen, Brenda W. Penninx, Esperanza Perucha, Anneli Pouta, Inga Prokopenko, Paul J. Roderick, Aimo Ruokonen, Nilesh J. Samani, Serena Sanna, Martin Schalling, David Schlessinger, Georg Schlieper, Marc A J Seelen, Alan R. Shuldiner, Marketa Sjögren, Johannes H. Smit, Harold Snieder, Nicole Soranzo, Timothy D. Spector, Peter Stenvinkel, Michael J E Sternberg, Ramasamyiyer Swaminathan, Toshiko Tanaka, Lielith J. Ubink-Veltmaat, Manuela Uda, Peter Vollenweider, Chris Wallace, Dawn Waterworth, Klaus Zerres, Gerard Waeber, Nicholas J. Wareham, Patrick H. Maxwell, Mark I. McCarthy, Marjo Riitta Jarvelin, Vincent Mooser, Goncalo R. Abecasis, Liz Lightstone, James Scott, Gerjan Navis, Paul Elliott, Jaspal S. Kooner

Research output: Contribution to journal › Article

Abstract

Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10 10 to 10 15). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 × 10 5 and P = 3.6 × 10 4, respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.

Original languageEnglish (US)
Pages (from-to)373-375
Number of pages3
JournalNature Genetics
Volume42
Issue number5
DOIs
StatePublished - May 2010
Externally publishedYes

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Genetic Loci
Chronic Renal Insufficiency
Kidney
Creatinine
Genome
Serum
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Genetics

Cite this

Chambers, J. C., Zhang, W., Lord, G. M., Van Der Harst, P., Lawlor, D. A., Sehmi, J. S., ... Kooner, J. S. (2010). Genetic loci influencing kidney function and chronic kidney disease. Nature Genetics, 42(5), 373-375. https://doi.org/10.1038/ng.566

Genetic loci influencing kidney function and chronic kidney disease. / Chambers, John C.; Zhang, Weihua; Lord, Graham M.; Van Der Harst, Pim; Lawlor, Debbie A.; Sehmi, Joban S.; Gale, Daniel P.; Wass, Mark N.; Ahmadi, Kourosh R.; Bakker, Stephan J L; Beckmann, Jacqui; Bilo, Henk J G; Bochud, Murielle; Brown, Morris J.; Caulfield, Mark J.; Connell, John M C; Cook, H. Terence; Cotlarciuc, Ioana; Smith, George Davey; De Silva, Ranil; Deng, Guohong; Devuyst, Olivier; Dikkeschei, Lambert D.; Dimkovic, Nada; Dockrell, Mark; Dominiczak, Anna; Ebrahim, Shah; Eggermann, Thomas; Farrall, Martin; Ferrucci, Luigi; Floege, Jurgen; Forouhi, Nita G.; Gansevoort, Ron T.; Han, Xijin; Hedblad, Bo; Van Der Heide, Jaap J Homan; Hepkema, Bouke G.; Hernandez-Fuentes, Maria; Hypponen, Elina; Johnson, Toby; De Jong, Paul E.; Kleefstra, Nanne; Lagou, Vasiliki; Lapsley, Marta; Li, Yun; Loos, Ruth J F; Luan, Jian'An; Luttropp, Karin; Maréchal, Céline; Melander, Olle; Munroe, Patricia B.; Nordfors, Louise; Parsa, Afshin; Peltonen, Leena; Penninx, Brenda W.; Perucha, Esperanza; Pouta, Anneli; Prokopenko, Inga; Roderick, Paul J.; Ruokonen, Aimo; Samani, Nilesh J.; Sanna, Serena; Schalling, Martin; Schlessinger, David; Schlieper, Georg; Seelen, Marc A J; Shuldiner, Alan R.; Sjögren, Marketa; Smit, Johannes H.; Snieder, Harold; Soranzo, Nicole; Spector, Timothy D.; Stenvinkel, Peter; Sternberg, Michael J E; Swaminathan, Ramasamyiyer; Tanaka, Toshiko; Ubink-Veltmaat, Lielith J.; Uda, Manuela; Vollenweider, Peter; Wallace, Chris; Waterworth, Dawn; Zerres, Klaus; Waeber, Gerard; Wareham, Nicholas J.; Maxwell, Patrick H.; McCarthy, Mark I.; Jarvelin, Marjo Riitta; Mooser, Vincent; Abecasis, Goncalo R.; Lightstone, Liz; Scott, James; Navis, Gerjan; Elliott, Paul; Kooner, Jaspal S.

In: Nature Genetics, Vol. 42, No. 5, 05.2010, p. 373-375.

Research output: Contribution to journal › Article

Chambers, JC, Zhang, W, Lord, GM, Van Der Harst, P, Lawlor, DA, Sehmi, JS, Gale, DP, Wass, MN, Ahmadi, KR, Bakker, SJL, Beckmann, J, Bilo, HJG, Bochud, M, Brown, MJ, Caulfield, MJ, Connell, JMC, Cook, HT, Cotlarciuc, I, Smith, GD, De Silva, R, Deng, G, Devuyst, O, Dikkeschei, LD, Dimkovic, N, Dockrell, M, Dominiczak, A, Ebrahim, S, Eggermann, T, Farrall, M, Ferrucci, L, Floege, J, Forouhi, NG, Gansevoort, RT, Han, X, Hedblad, B, Van Der Heide, JJH, Hepkema, BG, Hernandez-Fuentes, M, Hypponen, E, Johnson, T, De Jong, PE, Kleefstra, N, Lagou, V, Lapsley, M, Li, Y, Loos, RJF, Luan, JA, Luttropp, K, Maréchal, C, Melander, O, Munroe, PB, Nordfors, L, Parsa, A, Peltonen, L, Penninx, BW, Perucha, E, Pouta, A, Prokopenko, I, Roderick, PJ, Ruokonen, A, Samani, NJ, Sanna, S, Schalling, M, Schlessinger, D, Schlieper, G, Seelen, MAJ, Shuldiner, AR, Sjögren, M, Smit, JH, Snieder, H, Soranzo, N, Spector, TD, Stenvinkel, P, Sternberg, MJE, Swaminathan, R, Tanaka, T, Ubink-Veltmaat, LJ, Uda, M, Vollenweider, P, Wallace, C, Waterworth, D, Zerres, K, Waeber, G, Wareham, NJ, Maxwell, PH, McCarthy, MI, Jarvelin, MR, Mooser, V, Abecasis, GR, Lightstone, L, Scott, J, Navis, G, Elliott, P & Kooner, JS 2010, 'Genetic loci influencing kidney function and chronic kidney disease', Nature Genetics, vol. 42, no. 5, pp. 373-375. https://doi.org/10.1038/ng.566
Chambers JC, Zhang W, Lord GM, Van Der Harst P, Lawlor DA, Sehmi JS et al. Genetic loci influencing kidney function and chronic kidney disease. Nature Genetics. 2010 May;42(5):373-375. https://doi.org/10.1038/ng.566
Chambers, John C. ; Zhang, Weihua ; Lord, Graham M. ; Van Der Harst, Pim ; Lawlor, Debbie A. ; Sehmi, Joban S. ; Gale, Daniel P. ; Wass, Mark N. ; Ahmadi, Kourosh R. ; Bakker, Stephan J L ; Beckmann, Jacqui ; Bilo, Henk J G ; Bochud, Murielle ; Brown, Morris J. ; Caulfield, Mark J. ; Connell, John M C ; Cook, H. Terence ; Cotlarciuc, Ioana ; Smith, George Davey ; De Silva, Ranil ; Deng, Guohong ; Devuyst, Olivier ; Dikkeschei, Lambert D. ; Dimkovic, Nada ; Dockrell, Mark ; Dominiczak, Anna ; Ebrahim, Shah ; Eggermann, Thomas ; Farrall, Martin ; Ferrucci, Luigi ; Floege, Jurgen ; Forouhi, Nita G. ; Gansevoort, Ron T. ; Han, Xijin ; Hedblad, Bo ; Van Der Heide, Jaap J Homan ; Hepkema, Bouke G. ; Hernandez-Fuentes, Maria ; Hypponen, Elina ; Johnson, Toby ; De Jong, Paul E. ; Kleefstra, Nanne ; Lagou, Vasiliki ; Lapsley, Marta ; Li, Yun ; Loos, Ruth J F ; Luan, Jian'An ; Luttropp, Karin ; Maréchal, Céline ; Melander, Olle ; Munroe, Patricia B. ; Nordfors, Louise ; Parsa, Afshin ; Peltonen, Leena ; Penninx, Brenda W. ; Perucha, Esperanza ; Pouta, Anneli ; Prokopenko, Inga ; Roderick, Paul J. ; Ruokonen, Aimo ; Samani, Nilesh J. ; Sanna, Serena ; Schalling, Martin ; Schlessinger, David ; Schlieper, Georg ; Seelen, Marc A J ; Shuldiner, Alan R. ; Sjögren, Marketa ; Smit, Johannes H. ; Snieder, Harold ; Soranzo, Nicole ; Spector, Timothy D. ; Stenvinkel, Peter ; Sternberg, Michael J E ; Swaminathan, Ramasamyiyer ; Tanaka, Toshiko ; Ubink-Veltmaat, Lielith J. ; Uda, Manuela ; Vollenweider, Peter ; Wallace, Chris ; Waterworth, Dawn ; Zerres, Klaus ; Waeber, Gerard ; Wareham, Nicholas J. ; Maxwell, Patrick H. ; McCarthy, Mark I. ; Jarvelin, Marjo Riitta ; Mooser, Vincent ; Abecasis, Goncalo R. ; Lightstone, Liz ; Scott, James ; Navis, Gerjan ; Elliott, Paul ; Kooner, Jaspal S. / Genetic loci influencing kidney function and chronic kidney disease. In: Nature Genetics. 2010 ; Vol. 42, No. 5. pp. 373-375.
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T1 - Genetic loci influencing kidney function and chronic kidney disease

AU - Chambers, John C.

AU - Zhang, Weihua

AU - Lord, Graham M.

AU - Van Der Harst, Pim

AU - Lawlor, Debbie A.

AU - Sehmi, Joban S.

AU - Gale, Daniel P.

AU - Wass, Mark N.

AU - Ahmadi, Kourosh R.

AU - Bakker, Stephan J L

AU - Beckmann, Jacqui

AU - Bilo, Henk J G

AU - Bochud, Murielle

AU - Brown, Morris J.

AU - Caulfield, Mark J.

AU - Connell, John M C

AU - Cook, H. Terence

AU - Cotlarciuc, Ioana

AU - Smith, George Davey

AU - De Silva, Ranil

AU - Deng, Guohong

AU - Devuyst, Olivier

AU - Dikkeschei, Lambert D.

AU - Dimkovic, Nada

AU - Dockrell, Mark

AU - Dominiczak, Anna

AU - Ebrahim, Shah

AU - Eggermann, Thomas

AU - Farrall, Martin

AU - Ferrucci, Luigi

AU - Floege, Jurgen

AU - Forouhi, Nita G.

AU - Gansevoort, Ron T.

AU - Han, Xijin

AU - Hedblad, Bo

AU - Van Der Heide, Jaap J Homan

AU - Hepkema, Bouke G.

AU - Hernandez-Fuentes, Maria

AU - Hypponen, Elina

AU - Johnson, Toby

AU - De Jong, Paul E.

AU - Kleefstra, Nanne

AU - Lagou, Vasiliki

AU - Lapsley, Marta

AU - Li, Yun

AU - Loos, Ruth J F

AU - Luan, Jian'An

AU - Luttropp, Karin

AU - Maréchal, Céline

AU - Melander, Olle

AU - Munroe, Patricia B.

AU - Nordfors, Louise

AU - Parsa, Afshin

AU - Peltonen, Leena

AU - Penninx, Brenda W.

AU - Perucha, Esperanza

AU - Pouta, Anneli

AU - Prokopenko, Inga

AU - Roderick, Paul J.

AU - Ruokonen, Aimo

AU - Samani, Nilesh J.

AU - Sanna, Serena

AU - Schalling, Martin

AU - Schlessinger, David

AU - Schlieper, Georg

AU - Seelen, Marc A J

AU - Shuldiner, Alan R.

AU - Sjögren, Marketa

AU - Smit, Johannes H.

AU - Snieder, Harold

AU - Soranzo, Nicole

AU - Spector, Timothy D.

AU - Stenvinkel, Peter

AU - Sternberg, Michael J E

AU - Swaminathan, Ramasamyiyer

AU - Tanaka, Toshiko

AU - Ubink-Veltmaat, Lielith J.

AU - Uda, Manuela

AU - Vollenweider, Peter

AU - Wallace, Chris

AU - Waterworth, Dawn

AU - Zerres, Klaus

AU - Waeber, Gerard

AU - Wareham, Nicholas J.

AU - Maxwell, Patrick H.

AU - McCarthy, Mark I.

AU - Jarvelin, Marjo Riitta

AU - Mooser, Vincent

AU - Abecasis, Goncalo R.

AU - Lightstone, Liz

AU - Scott, James

AU - Navis, Gerjan

AU - Elliott, Paul

AU - Kooner, Jaspal S.

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AB - Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10 10 to 10 15). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 × 10 5 and P = 3.6 × 10 4, respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.

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