Genetic linkage of a novel autosomal dominant restrictive cardiomyopathy locus

J. Zhang, A. Kumar, L. Kaplan, F. J. Fricker, Margaret R. Wallace

Research output: Contribution to journalArticle

Abstract

Background: In recent years, non-syndromic idiopathic cardiomyopathies have increasingly been characterised as autosomal dominant conditions caused by single gene mutations. Loci have been identified for hypertrophic and dilated cardiomyopathy, and in some cases the same loci are associated with restrictive cardiomyopathy (RCM). In a kindred with RCM that we previously reported, we ruled out the known cardiomyopathy loci and other candidate genes by linkage analysis and mutation screening. Methods and Results: Here we report a genome-wide analysis in this family that has resulted in linkage to a region on chromosome 10. Conclusions: There are no genes in the interval that are known to cause idiopathic cardiomyopathy, and thus this linkage represents localisation of a new RCM locus.

Original languageEnglish (US)
Pages (from-to)663-665
Number of pages3
JournalJournal of Medical Genetics
Volume42
Issue number8
DOIs
StatePublished - Aug 2005

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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