Genetic landscape of human papillomavirus-associated head and neck cancer and comparison to tobacco-related tumors

D. Neil Hayes, Carter Van Waes, Tanguy Lim Seiwert

Research output: Contribution to journalReview article

Abstract

Head and neck cancer is the fifth most common cancer worldwide. It is often amenable to curative intent therapy when localized to the head and neck region, but it carries a poor prognosis when it is recurrent or metastatic. Therefore, initial treatment decisions are critical to improve patient survival. However, multimodality therapy used with curative intent is toxic. The balance between offering intensive versus tolerable and function-preserving therapy has been thrown into sharp relief with the recently described epidemic of human papillomavirus-associated head and neck squamous cell carcinomas characterized by improved clinical outcomes compared with smokingassociated head and neck tumors. Model systems and clinical trials have been slow to address the clinical questions that face the field to date. With this as a background, a host of translational studies have recently reported the somatic alterations in head and neck cancer and have highlighted the distinct genetic and biologic differences between viral and tobacco-associated tumors. This review seeks to summarize the main findings of studies, including The Cancer Genome Atlas, for the clinician scientist, with a goal of leveraging this new knowledge toward the betterment of patients with head and neck cancer.

Original languageEnglish (US)
Pages (from-to)3227-3234
Number of pages8
JournalJournal of Clinical Oncology
Volume33
Issue number29
DOIs
StatePublished - Oct 10 2015
Externally publishedYes

Fingerprint

Medical Genetics
Head and Neck Neoplasms
Tobacco
Neoplasms
Neck
Head
Atlases
Poisons
Therapeutics
Clinical Trials
Genome
Survival

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Genetic landscape of human papillomavirus-associated head and neck cancer and comparison to tobacco-related tumors. / Hayes, D. Neil; Van Waes, Carter; Lim Seiwert, Tanguy.

In: Journal of Clinical Oncology, Vol. 33, No. 29, 10.10.2015, p. 3227-3234.

Research output: Contribution to journalReview article

@article{2aa76593cb6f49e2857a8ba70b18654f,
title = "Genetic landscape of human papillomavirus-associated head and neck cancer and comparison to tobacco-related tumors",
abstract = "Head and neck cancer is the fifth most common cancer worldwide. It is often amenable to curative intent therapy when localized to the head and neck region, but it carries a poor prognosis when it is recurrent or metastatic. Therefore, initial treatment decisions are critical to improve patient survival. However, multimodality therapy used with curative intent is toxic. The balance between offering intensive versus tolerable and function-preserving therapy has been thrown into sharp relief with the recently described epidemic of human papillomavirus-associated head and neck squamous cell carcinomas characterized by improved clinical outcomes compared with smokingassociated head and neck tumors. Model systems and clinical trials have been slow to address the clinical questions that face the field to date. With this as a background, a host of translational studies have recently reported the somatic alterations in head and neck cancer and have highlighted the distinct genetic and biologic differences between viral and tobacco-associated tumors. This review seeks to summarize the main findings of studies, including The Cancer Genome Atlas, for the clinician scientist, with a goal of leveraging this new knowledge toward the betterment of patients with head and neck cancer.",
author = "Hayes, {D. Neil} and {Van Waes}, Carter and {Lim Seiwert}, Tanguy",
year = "2015",
month = "10",
day = "10",
doi = "10.1200/JCO.2015.62.1086",
language = "English (US)",
volume = "33",
pages = "3227--3234",
journal = "Journal of Clinical Oncology",
issn = "0732-183X",
publisher = "American Society of Clinical Oncology",
number = "29",

}

TY - JOUR

T1 - Genetic landscape of human papillomavirus-associated head and neck cancer and comparison to tobacco-related tumors

AU - Hayes, D. Neil

AU - Van Waes, Carter

AU - Lim Seiwert, Tanguy

PY - 2015/10/10

Y1 - 2015/10/10

N2 - Head and neck cancer is the fifth most common cancer worldwide. It is often amenable to curative intent therapy when localized to the head and neck region, but it carries a poor prognosis when it is recurrent or metastatic. Therefore, initial treatment decisions are critical to improve patient survival. However, multimodality therapy used with curative intent is toxic. The balance between offering intensive versus tolerable and function-preserving therapy has been thrown into sharp relief with the recently described epidemic of human papillomavirus-associated head and neck squamous cell carcinomas characterized by improved clinical outcomes compared with smokingassociated head and neck tumors. Model systems and clinical trials have been slow to address the clinical questions that face the field to date. With this as a background, a host of translational studies have recently reported the somatic alterations in head and neck cancer and have highlighted the distinct genetic and biologic differences between viral and tobacco-associated tumors. This review seeks to summarize the main findings of studies, including The Cancer Genome Atlas, for the clinician scientist, with a goal of leveraging this new knowledge toward the betterment of patients with head and neck cancer.

AB - Head and neck cancer is the fifth most common cancer worldwide. It is often amenable to curative intent therapy when localized to the head and neck region, but it carries a poor prognosis when it is recurrent or metastatic. Therefore, initial treatment decisions are critical to improve patient survival. However, multimodality therapy used with curative intent is toxic. The balance between offering intensive versus tolerable and function-preserving therapy has been thrown into sharp relief with the recently described epidemic of human papillomavirus-associated head and neck squamous cell carcinomas characterized by improved clinical outcomes compared with smokingassociated head and neck tumors. Model systems and clinical trials have been slow to address the clinical questions that face the field to date. With this as a background, a host of translational studies have recently reported the somatic alterations in head and neck cancer and have highlighted the distinct genetic and biologic differences between viral and tobacco-associated tumors. This review seeks to summarize the main findings of studies, including The Cancer Genome Atlas, for the clinician scientist, with a goal of leveraging this new knowledge toward the betterment of patients with head and neck cancer.

UR - http://www.scopus.com/inward/record.url?scp=84944245456&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84944245456&partnerID=8YFLogxK

U2 - 10.1200/JCO.2015.62.1086

DO - 10.1200/JCO.2015.62.1086

M3 - Review article

C2 - 26351353

AN - SCOPUS:84944245456

VL - 33

SP - 3227

EP - 3234

JO - Journal of Clinical Oncology

JF - Journal of Clinical Oncology

SN - 0732-183X

IS - 29

ER -