Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations

SpiroMeta consortium, International COPD Genetics Consortium, Understanding Society Scientific group

Research output: Contribution to journalArticle

Abstract

Chronic obstructive pulmonary disease (COPD) is the leading cause of respiratory mortality worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed a genome-wide association study in 35,735 cases and 222,076 controls from the UK Biobank and additional studies from the International COPD Genetics Consortium. We identified 82 loci associated with P < 5 × 10 −8 ; 47 of these were previously described in association with either COPD or population-based measures of lung function. Of the remaining 35 new loci, 13 were associated with lung function in 79,055 individuals from the SpiroMeta consortium. Using gene expression and regulation data, we identified functional enrichment of COPD risk loci in lung tissue, smooth muscle, and several lung cell types. We found 14 COPD loci shared with either asthma or pulmonary fibrosis. COPD genetic risk loci clustered into groups based on associations with quantitative imaging features and comorbidities. Our analyses provide further support for the genetic susceptibility and heterogeneity of COPD.

Original languageEnglish (US)
Pages (from-to)494-505
Number of pages12
JournalNature genetics
Volume51
Issue number3
DOIs
StatePublished - Mar 1 2019

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Chronic Obstructive Pulmonary Disease
Phenotype
Lung
Genetic Loci
Genetic Heterogeneity
Pulmonary Fibrosis
Genome-Wide Association Study
Gene Expression Regulation
Genetic Predisposition to Disease
Smooth Muscle
Comorbidity
Asthma
Mortality
Population

ASJC Scopus subject areas

  • Genetics

Cite this

SpiroMeta consortium, International COPD Genetics Consortium, & Understanding Society Scientific group (2019). Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations. Nature genetics, 51(3), 494-505. https://doi.org/10.1038/s41588-018-0342-2

Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations. / SpiroMeta consortium; International COPD Genetics Consortium; Understanding Society Scientific group.

In: Nature genetics, Vol. 51, No. 3, 01.03.2019, p. 494-505.

Research output: Contribution to journalArticle

SpiroMeta consortium, International COPD Genetics Consortium & Understanding Society Scientific group 2019, 'Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations', Nature genetics, vol. 51, no. 3, pp. 494-505. https://doi.org/10.1038/s41588-018-0342-2
SpiroMeta consortium, International COPD Genetics Consortium, Understanding Society Scientific group. Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations. Nature genetics. 2019 Mar 1;51(3):494-505. https://doi.org/10.1038/s41588-018-0342-2
SpiroMeta consortium ; International COPD Genetics Consortium ; Understanding Society Scientific group. / Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations. In: Nature genetics. 2019 ; Vol. 51, No. 3. pp. 494-505.
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