Genetic influences on spontaneous autoimmune thyroiditis in (CS x OS)F2 chickens

Larry D. Bacon; Carl R. Polley; Randall K. Cole; Noel R. Rose

doi:10.1007/BF01561675

Genetic influences on spontaneous autoimmune thyroiditis in (CS x OS)F₂ chickens

Larry D. Bacon, Carl R. Polley, Randall K. Cole, Noel R. Rose

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Genetic effects on spontaneous autoimmune thyroiditis in chickens were assessed by measuring phenotypic symptoms, the titer of circulating antibody to thyroglobulin, and the pathological change in the thyroids of young chicks. One or more loci within the B complex (the major histocompatibility complex of the chicken) are responsible for the expression of autoimmunity, and evidence is provided for an interaction of the B haplotype with genes at other loci. The influence of the B complex component on genetic susceptibility is more visible in animals with limited susceptibility at other loci and becomes indistinguishable as the frequency of other genes determining thyroid autoimmunity increases.

Original language	English (US)
Pages (from-to)	339-349
Number of pages	11
Journal	Immunogenetics
Volume	12
Issue number	1
DOIs	https://doi.org/10.1007/BF01561675
State	Published - Dec 1981
Externally published	Yes

ASJC Scopus subject areas

Immunology
Genetics

Access to Document

10.1007/BF01561675

Cite this

@article{414d9323b5e149368d0fd531dc334bf8,

title = "Genetic influences on spontaneous autoimmune thyroiditis in (CS x OS)F2 chickens",

abstract = "Genetic effects on spontaneous autoimmune thyroiditis in chickens were assessed by measuring phenotypic symptoms, the titer of circulating antibody to thyroglobulin, and the pathological change in the thyroids of young chicks. One or more loci within the B complex (the major histocompatibility complex of the chicken) are responsible for the expression of autoimmunity, and evidence is provided for an interaction of the B haplotype with genes at other loci. The influence of the B complex component on genetic susceptibility is more visible in animals with limited susceptibility at other loci and becomes indistinguishable as the frequency of other genes determining thyroid autoimmunity increases.",

author = "Bacon, {Larry D.} and Polley, {Carl R.} and Cole, {Randall K.} and Rose, {Noel R.}",

year = "1981",

month = dec,

doi = "10.1007/BF01561675",

language = "English (US)",

volume = "12",

pages = "339--349",

journal = "Immunogenetics",

issn = "0093-7711",

publisher = "Springer Verlag",

number = "1",

}

TY - JOUR

T1 - Genetic influences on spontaneous autoimmune thyroiditis in (CS x OS)F2 chickens

AU - Bacon, Larry D.

AU - Polley, Carl R.

AU - Cole, Randall K.

AU - Rose, Noel R.

PY - 1981/12

Y1 - 1981/12

N2 - Genetic effects on spontaneous autoimmune thyroiditis in chickens were assessed by measuring phenotypic symptoms, the titer of circulating antibody to thyroglobulin, and the pathological change in the thyroids of young chicks. One or more loci within the B complex (the major histocompatibility complex of the chicken) are responsible for the expression of autoimmunity, and evidence is provided for an interaction of the B haplotype with genes at other loci. The influence of the B complex component on genetic susceptibility is more visible in animals with limited susceptibility at other loci and becomes indistinguishable as the frequency of other genes determining thyroid autoimmunity increases.

AB - Genetic effects on spontaneous autoimmune thyroiditis in chickens were assessed by measuring phenotypic symptoms, the titer of circulating antibody to thyroglobulin, and the pathological change in the thyroids of young chicks. One or more loci within the B complex (the major histocompatibility complex of the chicken) are responsible for the expression of autoimmunity, and evidence is provided for an interaction of the B haplotype with genes at other loci. The influence of the B complex component on genetic susceptibility is more visible in animals with limited susceptibility at other loci and becomes indistinguishable as the frequency of other genes determining thyroid autoimmunity increases.

UR - http://www.scopus.com/inward/record.url?scp=0019447030&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019447030&partnerID=8YFLogxK

U2 - 10.1007/BF01561675

DO - 10.1007/BF01561675

M3 - Article

C2 - 7203560

AN - SCOPUS:0019447030

SN - 0093-7711

VL - 12

SP - 339

EP - 349

JO - Immunogenetics

JF - Immunogenetics

IS - 1

ER -

Genetic influences on spontaneous autoimmune thyroiditis in (CS x OS)F₂ chickens

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this