Genetic influences of resting state fMRI activity in language-related brain regions in healthy controls and schizophrenia patients: A pilot study

Sharna Jamadar, Natalie R. Powers, Shashwath A. Meda, Vince D. Calhoun, Joel Gelernter, Jeffrey R. Gruen, Godfrey D. Pearlson

    Research output: Contribution to journalArticlepeer-review


    Individuals with schizophrenia show a broad range of language impairments, similar to those observed in reading disability (RD). Genetic linkage and association studies of RD have identified a number of candidate RD-genes that are associated with neuronal migration. Some individuals with schizophrenia also show evidence of impaired cortical neuronal migration. We have previously linked RD-related genes with gray matter distributions in healthy controls and schizophrenia. The aim of the current study was to extend these structural findings and to examine links between putative RD-genes and functional connectivity of language-related regions in healthy controls (n = 27) and schizophrenia (n = 28). Parallel independent component analysis (parallel-ICA) was used to examine the relationship between language-related regions extracted from resting-state fMRI and 16 single nucleotide polymorphisms (SNPs) spanning 5 RD-related genes. Parallel-ICA identified four significant fMRI-SNP relationships. A Left Broca-Superior/Inferior Parietal network was related to two KIAA0319 SNPs in controls but not in schizophrenia. For both diagnostic groups, a Broca-Medial Parietal network was related to two DCDC2 SNPs, while a Left Wernicke-Fronto-Occipital network was related to two KIAA0319 SNPs. A Bilateral Wernicke-Fronto-Parietal network was related to one KIAA0319 SNP only in controls. Thus, RD-genes influence functional connectivity in language-related regions, but no RD-gene uniquely affected network function in schizophrenia as compared to controls. This is in contrast with our previous study where RD-genes affected gray matter distribution in some structural networks in schizophrenia but not in controls. Thus these RD-genes may exert a more important influence on structure rather than function of language-related networks in schizophrenia.

    Original languageEnglish (US)
    Pages (from-to)15-27
    Number of pages13
    JournalBrain Imaging and Behavior
    Issue number1
    StatePublished - Jan 1 2013


    • Dyslexia genes
    • Independent component analysis
    • Language
    • Reading
    • Resting state fMRI

    ASJC Scopus subject areas

    • Radiology Nuclear Medicine and imaging
    • Neurology
    • Cognitive Neuroscience
    • Clinical Neurology
    • Cellular and Molecular Neuroscience
    • Psychiatry and Mental health
    • Behavioral Neuroscience

    Fingerprint Dive into the research topics of 'Genetic influences of resting state fMRI activity in language-related brain regions in healthy controls and schizophrenia patients: A pilot study'. Together they form a unique fingerprint.

    Cite this