Genetic influence on appetite in children

Susan Carnell, C. M A Haworth, R. Plomin, J. Wardle

Research output: Contribution to journalArticle

Abstract

Background: The modern environment is ubiquitously 'obesogenic', yet people vary enormously in weight. One factor contributing to weight variation could be genetically determined differences in appetite that modulate susceptibility to the environment. We assessed the relative contribution of genes and environment for two aspects of appetite that have been implicated in obesity. Methods: Parents of a population-based sample of 8- to 11-year-old twins (n=5435 pairs) completed validated, questionnaire measures of responsiveness to satiety and responsiveness to food cues for both children. Results: Quantitative genetic model fitting gave estimates of 63% (95% confidence interval: 39-81%) for the heritability of satiety responsiveness and 75% (52-85%) for food cue responsiveness. Shared and non-shared environmental influences were 21% (0-51%) and 16% (10-21%) for satiety responsiveness, and 10% (0-38%) and 15% (10-18%) for food cue responsiveness, respectively. Conclusions: The high heritability of appetitive traits that are known to be related to weight suggests that genetic vulnerability to weight gain could operate through behavioural as well as metabolic pathways. Intervention strategies aimed at improving satiety responsiveness and reducing food cue responsiveness in high-risk individuals could help in preventing the development of obesity.

LanguageEnglish (US)
Pages1468-1473
Number of pages6
JournalInternational Journal of Obesity
Volume32
Issue number10
DOIs
StatePublished - Oct 2008
Externally publishedYes

Fingerprint

Appetite
Cues
Food
Weights and Measures
Obesity
Genetic Models
Metabolic Networks and Pathways
Weight Gain
Parents
Confidence Intervals
Population
Genes

Keywords

  • Appetite
  • Children
  • Eating behaviour

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Endocrinology, Diabetes and Metabolism

Cite this

Genetic influence on appetite in children. / Carnell, Susan; Haworth, C. M A; Plomin, R.; Wardle, J.

In: International Journal of Obesity, Vol. 32, No. 10, 10.2008, p. 1468-1473.

Research output: Contribution to journalArticle

Carnell, S, Haworth, CMA, Plomin, R & Wardle, J 2008, 'Genetic influence on appetite in children' International Journal of Obesity, vol. 32, no. 10, pp. 1468-1473. https://doi.org/10.1038/ijo.2008.127
Carnell, Susan ; Haworth, C. M A ; Plomin, R. ; Wardle, J. / Genetic influence on appetite in children. In: International Journal of Obesity. 2008 ; Vol. 32, No. 10. pp. 1468-1473.
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