Genetic factors associated with slow progression of HIV among perinatally-infected Indian children

Riya Pal Chaudhuri; Ujjwal Neogi; Shwetha D. Rao; Anita Shet

doi:10.1007/s13312-014-0505-x

Genetic factors associated with slow progression of HIV among perinatally-infected Indian children

Riya Pal Chaudhuri, Ujjwal Neogi, Shwetha D. Rao, Anita Shet

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Objectives: To study the association between common AIDS restriction genes and slow disease progression among perinatally-infected children in India.

Methods: ART-naïve children were identified and selected host factors including CCR5-Δ32, SDF1-3’A, CCR5-59029G, HLA-B*27, B*57 were studied using allele-specific PCR-RFLP and SSPGo HLA typing kits.

Results: Among 165 children, 10 (6%) long-term non-progressors and 8 (5%) slow progressors were identified. For comparison, 12 children with normal progression of HIV were included. The frequencies of CCR5-Δ32 deletion, SDF1-3’A and CCR5-59029G did not differ significantly. HLA-B*27 and B*57 were observed only in long-term non-progressors or slow progressors, who also harbored either SDF1-3’A and/or CCR5-59029G.

Conclusions: There is an association between host genetic factors and slow disease progression in this population.

Original language	English (US)
Pages (from-to)	801-803
Number of pages	3
Journal	Indian pediatrics
Volume	51
Issue number	10
DOIs	https://doi.org/10.1007/s13312-014-0505-x
State	Published - Oct 2014
Externally published	Yes

Keywords

Genetics
Human Immunodeficiency virus
Outcome
Progression

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1007/s13312-014-0505-x

Cite this

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title = "Genetic factors associated with slow progression of HIV among perinatally-infected Indian children",

abstract = "Objectives: To study the association between common AIDS restriction genes and slow disease progression among perinatally-infected children in India.Methods: ART-na{\"i}ve children were identified and selected host factors including CCR5-Δ32, SDF1-3{\textquoteright}A, CCR5-59029G, HLA-B*27, B*57 were studied using allele-specific PCR-RFLP and SSPGo HLA typing kits.Results: Among 165 children, 10 (6%) long-term non-progressors and 8 (5%) slow progressors were identified. For comparison, 12 children with normal progression of HIV were included. The frequencies of CCR5-Δ32 deletion, SDF1-3{\textquoteright}A and CCR5-59029G did not differ significantly. HLA-B*27 and B*57 were observed only in long-term non-progressors or slow progressors, who also harbored either SDF1-3{\textquoteright}A and/or CCR5-59029G.Conclusions: There is an association between host genetic factors and slow disease progression in this population.",

keywords = "Genetics, Human Immunodeficiency virus, Outcome, Progression",

author = "Chaudhuri, {Riya Pal} and Ujjwal Neogi and Rao, {Shwetha D.} and Anita Shet",

note = "Publisher Copyright: {\textcopyright} 2014, Indian Academy of Pediatrics.",

year = "2014",

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doi = "10.1007/s13312-014-0505-x",

language = "English (US)",

volume = "51",

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T1 - Genetic factors associated with slow progression of HIV among perinatally-infected Indian children

AU - Chaudhuri, Riya Pal

AU - Neogi, Ujjwal

AU - Rao, Shwetha D.

AU - Shet, Anita

PY - 2014/10

Y1 - 2014/10

N2 - Objectives: To study the association between common AIDS restriction genes and slow disease progression among perinatally-infected children in India.Methods: ART-naïve children were identified and selected host factors including CCR5-Δ32, SDF1-3’A, CCR5-59029G, HLA-B*27, B*57 were studied using allele-specific PCR-RFLP and SSPGo HLA typing kits.Results: Among 165 children, 10 (6%) long-term non-progressors and 8 (5%) slow progressors were identified. For comparison, 12 children with normal progression of HIV were included. The frequencies of CCR5-Δ32 deletion, SDF1-3’A and CCR5-59029G did not differ significantly. HLA-B*27 and B*57 were observed only in long-term non-progressors or slow progressors, who also harbored either SDF1-3’A and/or CCR5-59029G.Conclusions: There is an association between host genetic factors and slow disease progression in this population.

AB - Objectives: To study the association between common AIDS restriction genes and slow disease progression among perinatally-infected children in India.Methods: ART-naïve children were identified and selected host factors including CCR5-Δ32, SDF1-3’A, CCR5-59029G, HLA-B*27, B*57 were studied using allele-specific PCR-RFLP and SSPGo HLA typing kits.Results: Among 165 children, 10 (6%) long-term non-progressors and 8 (5%) slow progressors were identified. For comparison, 12 children with normal progression of HIV were included. The frequencies of CCR5-Δ32 deletion, SDF1-3’A and CCR5-59029G did not differ significantly. HLA-B*27 and B*57 were observed only in long-term non-progressors or slow progressors, who also harbored either SDF1-3’A and/or CCR5-59029G.Conclusions: There is an association between host genetic factors and slow disease progression in this population.

KW - Genetics

KW - Human Immunodeficiency virus

KW - Outcome

KW - Progression

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Genetic factors associated with slow progression of HIV among perinatally-infected Indian children

Abstract

Keywords

ASJC Scopus subject areas

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