Genetic factors associated with slow progression of HIV among perinatally-infected Indian children

Riya Pal Chaudhuri, Ujjwal Neogi, Shwetha D. Rao, Anita Shet

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: To study the association between common AIDS restriction genes and slow disease progression among perinatally-infected children in India.

Methods: ART-naïve children were identified and selected host factors including CCR5-Δ32, SDF1-3’A, CCR5-59029G, HLA-B*27, B*57 were studied using allele-specific PCR-RFLP and SSPGo HLA typing kits.

Results: Among 165 children, 10 (6%) long-term non-progressors and 8 (5%) slow progressors were identified. For comparison, 12 children with normal progression of HIV were included. The frequencies of CCR5-Δ32 deletion, SDF1-3’A and CCR5-59029G did not differ significantly. HLA-B*27 and B*57 were observed only in long-term non-progressors or slow progressors, who also harbored either SDF1-3’A and/or CCR5-59029G.

Conclusions: There is an association between host genetic factors and slow disease progression in this population.

Original languageEnglish (US)
Pages (from-to)801-803
Number of pages3
JournalIndian pediatrics
Volume51
Issue number10
DOIs
StatePublished - Oct 2014
Externally publishedYes

Keywords

  • Genetics
  • Human Immunodeficiency virus
  • Outcome
  • Progression

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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