Genetic evolution of pancreatic cancer: Lessons learnt from the pancreatic cancer genome sequencing project

Christine A. Iacobuzio-Donahue

Research output: Contribution to journalArticle

Abstract

Pancreatic cancer is a disease caused by the accumulation of genetic alterations in specific genes. Elucidation of the human genome sequence, in conjunction with technical advances in the ability to perform whole exome sequencing, have provided new insight into the mutational spectra characteristic of this lethal tumour type. Most recently, exomic sequencing has been used to clarify the clonal evolution of pancreatic cancer as well as provide time estimates of pancreatic carcinogenesis, indicating that a long window of opportunity may exist for early detection of this disease while in the curative stage. Moving forward, these mutational analyses indicate potential targets for personalised diagnostic and therapeutic intervention as well as the optimal timing for intervention based on the natural history of pancreatic carcinogenesis and progression.

Original languageEnglish (US)
Pages (from-to)1085-1094
Number of pages10
JournalGut
Volume61
Issue number7
DOIs
StatePublished - Jul 2012

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Molecular Evolution
Pancreatic Neoplasms
Carcinogenesis
Genome
Clonal Evolution
Exome
Human Genome
Early Diagnosis
Genes
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Genetic evolution of pancreatic cancer : Lessons learnt from the pancreatic cancer genome sequencing project. / Iacobuzio-Donahue, Christine A.

In: Gut, Vol. 61, No. 7, 07.2012, p. 1085-1094.

Research output: Contribution to journalArticle

Iacobuzio-Donahue, Christine A. / Genetic evolution of pancreatic cancer : Lessons learnt from the pancreatic cancer genome sequencing project. In: Gut. 2012 ; Vol. 61, No. 7. pp. 1085-1094.
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