Genetic etiology of hereditary prostate cancer

Wendy J. Langeberg, William B. Isaacs, Janet L. Stanford

Research output: Contribution to journalArticle

Abstract

Prostate cancer (PC) is a pervasive disease both in terms of incidence and mortality, yet little is known about its etiologic factors. Twin and segregation studies provide evidence for an inherited genetic component to the etiology of PC, yet over a dozen family-based genetic linkage analyses have not been able to consistently identify susceptibility loci. This chapter will review these studies, describe the challenges of this endeavor, and describe efforts to confront these challenges, such as using larger sets of families and more homogeneous subgroups.

Original languageEnglish (US)
Pages (from-to)4101-4110
Number of pages10
JournalFrontiers in Bioscience
Volume12
Issue number11
DOIs
StatePublished - May 1 2007

    Fingerprint

Keywords

  • Genetic linkage
  • Hereditary
  • Prostate cancer
  • Review
  • Susceptibility genes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this